| Revision as of 22:02, 1 June 2006 editColin (talk | contribs)Autopatrolled, Extended confirmed users, File movers, Pending changes reviewers, Rollbackers18,958 editsm moved J&J Brand category to Levaquin← Previous edit | Revision as of 00:25, 8 June 2006 edit undo201.37.169.136 (talk)No edit summaryNext edit → | ||
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Revision as of 00:25, 8 June 2006
This template is misplaced. It belongs on the talk page: Talk:Levofloxacin. | This article has a deprecated, substituted or incorrect infobox and needs a new one. Please consult the relevant WikiProject or Infobox templates category to find an appropriate replacement. |
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| (-)-(S)-9-fluoro-2,3-dihydro-3-methyl- 10-(4-methyl-1-piperazinyl)-7-oxo- 7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid | |
| CAS number 100986-85-4 |
ATC code J01MA12, S01AX19 |
| Chemical formula | C18H20FN3O4 |
| Molecular weight | 361.371 |
| Bioavailability | 100% |
| Metabolism | slightly |
| Elimination half-life | 6-8 hrs |
| Excretion | Urine (> 85%) |
| Pregnancy category | not to be used |
| Legal status | ? |
| Routes of administration | oral and iv |
Levofloxacin is a fluoroquinolone antibiotic, marketed by Ortho-McNeil under the trade name Levaquin. Chemically, levofloxacin is the S-enantiomer (L-isomer) of ofloxacin.
Levofloxacin is effective against a number of gram-positive and gram-negative bacteria. Because of its broad spectrum of action, levofloxacin is frequently prescribed empirically for a wide range of infections (e.g. pneumonia, urinary tract infection) before the specific causal organism is known. If the causal organism is identified, levofloxacin may be discontinued and the patient may be switched to an antibiotic with a narrower spectrum of activity.
Gram-positive bacteria
- Enterococcus faecalis (many strains are only moderately susceptible)
- Staphylococcus aureus (methicillin-susceptible strains)
- Staphylococcus epidermidis (methicillin-susceptible strains)
- Staphylococcus saprophyticus
- Streptococcus pneumoniae (including penicillin-resistant strains*)
- Streptococcus pyogenes
Levofloxacin only has moderate Gram-positive coverage; beta-lactams (e.g. ceftriaxone) or glycopeptides (e.g. vancomycin) are generally preferred for this indication.
Gram-negative bacteria
- Enterobacter cloacae
- Klebsiella pneumoniae
- Pseudomonas aeruginosa
- Escherichia coli
- Legionella pneumophila
- Serratia marcescens
- Haemophilus influenzae
- Moraxella catarrhalis
- Haemophilus parainfluenzae
- Proteus mirabilis
- Campylobacter
Other
Some information extracted from Levaquin Prescribing information.
| Antibacterials that inhibit nucleic acid (J01E, J01M) | |||||||||||||||||
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| Antifolates (inhibit bacterial purine metabolism, thereby inhibiting DNA and RNA synthesis) |
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| Quinolones (inhibit bacterial topoisomerase and/or DNA gyrase, thereby inhibiting DNA replication) |
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| Anaerobic DNA inhibitors |
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| RNA synthesis |
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