Misplaced Pages

This is an old revision of this page, as edited by Smokefoot (talk | contribs) at 22:40, 27 April 2016 (rm side effects section. Too much detail.). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Satraplatin

Clinical data
Other names	BMY 45594 BMS 182751 (OC-6-43)-bis(acetato)amminedichlorocyclohexylamine platinum(IV)
Routes of administration	Oral
ATC code	L01XA04 (WHO)
Identifiers
IUPAC name (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum
CAS Number	129580-63-8
PubChem CID	123974
UNII	8D7B37T28G
ChEBI	CHEBI:85609
CompTox Dashboard (EPA)	DTXSID00926438
Chemical and physical data
Formula	C10H22Cl2N2O4Pt
Molar mass	500.277 g/mol g·mol
(verify)

Satraplatin (INN, codenamed JM216) is a platinum-based antineoplastic agent that is under investigation as one treatment of patients with advanced prostate cancer who have failed previous chemotherapy. It has not yet received approval from the U.S. Food and Drug Administration. First mentioned in the medical literature in 1993, satraplatin is the first orally active platinum-based chemotherapeutic drug; other available platinum analogues—cisplatin, carboplatin, and oxaliplatin—must be given intravenously.

It is made available in the United States jointly by Spectrum Pharmaceuticals and GPC Biotech under the name SPERA (SatraPlatin Expanded Rapid Access).

The drug has also been used in the treatment of lung and ovarian cancers. The proposed mode of action is that the compound binds to the DNA of cancer cells rendering them incapable of dividing.

Medical Use

Satraplatin is an orally bioavailable platinum chemotherapeutic agent under development for several cancer types, including hormone-refractory prostate cancer (HRPC). Satraplatin is being developed for the treatment of men with chemorefractory HRPC for several reasons. It's relative ease of administration, potential lack of cross-resistance with other platinum agents, clinical benefits seen in early studies of HRPC, and an unmet need in this patient population after Docetaxel failure. Satraplatin may provide a palliative benefit for patients in terms of progression-free survival according to the most recent analyses of the phase III SPARC trial, and is currently under Food and Drug Administration review for this indication. Whether satraplatin and prednisone offer an advantage over docetaxel retreatment or other cytotoxic agents in this setting is under investigation.

Satraplatin has a favorable toxicity profile, and appears to have clinical activity against a variety of malignancies such as Breast Cancer, Prostate cancer and Lung cancer. The oral route of administration and the intermittent schedule makes it very convenient for clinical use. Despite this, a FDA-approved indication has not yet been achieved. The only Phase III trial with satraplatin was conducted in pre-treated metastatic prostate cancer(CRPC), revealing an improvement in progression-free survival but no overall survival benefit. 

References

1. Wheate, Nial J.; Walker, Shonagh; Craig, Gemma E.; Oun, Rabbab (2010). "The status of platinum anticancer drugs in the clinic and in clinical trials". Dalton Transactions. 39 (35): 8113–27. doi:10.1039/C0DT00292E. PMID 20593091.
2. Kelland LR, Abel G, McKeage MJ, et al. (1993). "Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum(IV): an orally active platinum drug" (PDF). Cancer Res. 53 (11): 2581–6. PMID 8388318.
3. Choy H, Park C, Yao M (2008). "Current status and future prospects for satraplatin, an oral platinum analogue". Clin Cancer Res. 14 (6): 1633–8. doi:10.1158/1078-0432.CCR-07-2176. PMID 18347164.{{cite journal}}: CS1 maint: multiple names: authors list (link)
4. Satraplatin — Spectrum Pharmaceuticals
5. Choy, Hak; Park, Clinton; Yao, Min (2008). "Current Status and Future Prospects for Satraplatin, an Oral Platinum Analogue". Clin Cancer Res. 14; 1633 doi: 10.1158/1078-0432.CCR-07-2176
6.  Vaishampayan UN. (2009) "Satraplatin: Leading the new generation of oral platinum agents." Expert opinion on investigational drugs." ;18(11):10.1517/13543780903362437. doi:10.1517/13543780903362437.

• Coordination compounds
• Platinum compounds
• Acetates
• Platinum-based antineoplastic agents