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A-41988

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Chemical compound Pharmaceutical compound
A-41988
Identifiers
IUPAC name
  • 8--5,5-dimethyl-2-prop-2-ynyl-3,4-dihydro-1H-chromenopyridin-10-ol
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC28H32FNO2
Molar mass433.567 g·mol
3D model (JSmol)
SMILES
  • c4cc(F)ccc4CCCC(C)c3cc(O)c1C=2CN(CC#C)CCC=2C(C)(C)Oc1c3
InChI
  • InChI=1S/C28H32FNO2/c1-5-14-30-15-13-24-23(18-30)27-25(31)16-21(17-26(27)32-28(24,3)4)19(2)7-6-8-20-9-11-22(29)12-10-20/h1,9-12,16-17,19,31H,6-8,13-15,18H2,2-4H3
  • Key:UIDOJGIFVOOMLY-UHFFFAOYSA-N
  (verify)

A-41988 (BW29Y) is an analgesic drug which acts as a cannabinoid agonist. It was developed by Abbott Laboratories in the 1970s, and researched for potential use in the treatment of glaucoma, but never commercialised.

See also

References

  1. Winn M, Arendsen D, Dodge P, Dren A, Dunnigan D, Hallas R, et al. (April 1976). "Drugs derived from cannabinoids. 5. delta6a,10a-Tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains". Journal of Medicinal Chemistry. 19 (4): 461–71. doi:10.1021/jm00226a003. PMID 817021.
  2. Guterman A, Somani P, Bachand RT (1979). "Phase-I evaluation of 5-5-dimethyl-10-hydroxy-8--2-(2-propynyl-1, 2, 3, 4-tetrahydro-5h- benzopyrano pyridine (a-41988)-novel benzopyran derivative". Clinical Pharmacology and Therapeutics. 25: 227.
  3. Tiedeman JS, Shields MB, Weber PA, Crow JW, Cocchetto DM, Harris WA, Howes JF (March 1981). "Effect of synthetic cannabinoids on elevated intraocular pressure". Ophthalmology. 88 (3): 270–7. doi:10.1016/s0161-6420(81)35052-0. PMID 7015221.
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