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O-1057

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Analgesic cannabinoid derivative Pharmaceutical compound
O-1057
Identifiers
IUPAC name
  • 3-(5'-cyano-1',1'-dimethylpentyl)-1-(4-N-morpholinobutyryloxy)-Δ-tetrahydrocannabinol
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC32H46N2O4
Molar mass522.730 g·mol
3D model (JSmol)
SMILES
  • N#CCCCCC(c3cc1OC(4C/C=C(\CC4c1c(OC(=O)CCCN2CCOCC2)c3)C)(C)C)(C)C
InChI
  • InChI=1S/C32H46N2O4/c1-23-11-12-26-25(20-23)30-27(37-29(35)10-9-15-34-16-18-36-19-17-34)21-24(22-28(30)38-32(26,4)5)31(2,3)13-7-6-8-14-33/h11,21-22,25-26H,6-10,12-13,15-20H2,1-5H3/t25-,26-/m1/s1
  • Key:YRDNBEPFVBMTNP-CLJLJLNGSA-N
  (verify)

O-1057 is an analgesic cannabinoid derivative created by Organix Inc., Newburyport, Massachusetts, for use in scientific research. Unlike most cannabinoids discovered to date, it is water-soluble, which gives it considerable advantages over many related cannabinoids. It has moderate affinity for both CB1 and CB2 receptors, with Ki values of 8.36 nM at CB1 and 7.95 nM at CB2

See also

References

  1. Pertwee RG, Gibson TM, Stevenson LA, Ross RA, Banner WK, Saha B, Razdan RK, Martin BR (April 2000). "O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive properties". British Journal of Pharmacology. 129 (8): 1577–84. doi:10.1038/sj.bjp.0703245. PMC 1572002. PMID 10780961.
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