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AGN-2979

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Chemical compound Pharmaceutical compound
AGN-2979
Clinical data
ATC code
  • None
Identifiers
IUPAC name
  • 3-(3-Dimethylaminopropyl)-3-(3-methoxyphenyl)-4,4-dimethyl-piperidine-2,6-dione
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H28N2O3
Molar mass332.444 g·mol
3D model (JSmol)
SMILES
  • O=C1NC(=O)CC(C1(c2cccc(OC)c2)CCCN(C)C)(C)C
InChI
  • InChI=1S/C19H28N2O3/c1-18(2)13-16(22)20-17(23)19(18,10-7-11-21(3)4)14-8-6-9-15(12-14)24-5/h6,8-9,12H,7,10-11,13H2,1-5H3,(H,20,22,23)
  • Key:UJFNSGBGJMRZKS-UHFFFAOYSA-N
  (what is this?)  (verify)

AGN-2979 is a glutarimide tryptophan hydroxylase activation inhibitor. It shows antidepressant properties in rodent models of depression.

References

  1. Hasegawa S, Kanemaru K, Gittos M, Diksic M (October 2005). "The tryptophan hydroxylase activation inhibitor, AGN-2979, decreases regional 5-HT synthesis in the rat brain measured with alpha-methyl-L-tryptophan: an autoradiographic study". Brain Research Bulletin. 67 (3): 248–55. doi:10.1016/j.brainresbull.2005.07.009. PMID 16144662. S2CID 41905586.
  2. ^ Gittos MW, Papp M (October 2001). "Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats". European Neuropsychopharmacology. 11 (5): 351–7. doi:10.1016/S0924-977X(01)00103-1. PMID 11597821. S2CID 46635727.
Monoamine metabolism modulators
Non-specific
AAADTooltip Aromatic L-amino acid decarboxylase
MAOTooltip Monoamine oxidase
Phenethylamines
(dopamine, epinephrine,
norepinephrine)
PAHTooltip Phenylalanine hydroxylase
THTooltip Tyrosine hydroxylase
DBHTooltip Dopamine beta-hydroxylase
PNMTTooltip Phenylethanolamine N-methyltransferase
COMTTooltip Catechol-O-methyl transferase
Tryptamines
(serotonin, melatonin)
TPHTooltip Tryptophan hydroxylase
AANATTooltip Serotonin N-acetyl transferase
ASMTTooltip Acetylserotonin O-methyltransferase
Histamine
HDCTooltip Histidine decarboxylase
HNMTTooltip Histamine N-methyltransferase
DAOTooltip Diamine oxidase
See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine neurotoxins
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