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SKF-91488

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SKF-91488
Names
Preferred IUPAC name 4-(Dimethylamino)butyl carbamimidothioate
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
DrugBank
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C7H17N3S/c1-10(2)5-3-4-6-11-7(8)9/h3-6H2,1-2H3,(H3,8,9)Key: UFYJLJINUGVUHO-UHFFFAOYSA-N
SMILES
  • /N=C(/N)\SCCCCN(C)C
Properties
Chemical formula C7H17N3S
Molar mass 175.29 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

SKF-91488 is a histamine N-methyltransferase inhibitor. It prevents the degradation of histamine, leading to increased histamine levels.

See also

References

  1. Thakkar, Mahesh M. (February 2011). "Histamine in the regulation of wakefulness". Sleep Medicine Reviews. 15 (1): 65–74. doi:10.1016/j.smrv.2010.06.004. PMC 3016451. PMID 20851648.
  2. Tamaoki, J.; Chiyotani, A.; Tagaya, E.; Isono, K.; Konno, K. (1994). "Histamine N-methyltransferase Modulates Human Bronchial Smooth Muscle Contraction". Mediators of Inflammation. 3 (2): 125–129. doi:10.1155/S0962935194000153. PMC 2367027. PMID 18472930.
Monoamine metabolism modulators
Non-specific
AAADTooltip Aromatic L-amino acid decarboxylase
MAOTooltip Monoamine oxidase
Phenethylamines
(dopamine, epinephrine,
norepinephrine)
PAHTooltip Phenylalanine hydroxylase
THTooltip Tyrosine hydroxylase
DBHTooltip Dopamine beta-hydroxylase
PNMTTooltip Phenylethanolamine N-methyltransferase
COMTTooltip Catechol-O-methyl transferase
Tryptamines
(serotonin, melatonin)
TPHTooltip Tryptophan hydroxylase
AANATTooltip Serotonin N-acetyl transferase
ASMTTooltip Acetylserotonin O-methyltransferase
Histamine
HDCTooltip Histidine decarboxylase
HNMTTooltip Histamine N-methyltransferase
DAOTooltip Diamine oxidase
See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine neurotoxins
Categories: