Decoglurant - Misplaced Pages

Chemical compound Pharmaceutical compound

Decoglurant
Clinical data

ATC code	none
Legal status
Legal status	Development terminated
Identifiers
IUPAC name 5-({7-(Trifluoromethyl)-5-pyrazolopyrimidin-3-yl}ethynyl)-2-pyridinamine
CAS Number	911115-16-7
PubChem CID	71533696
ChemSpider	32695160
UNII	5VX4P0JKC5
KEGG	D10875
CompTox Dashboard (EPA)	DTXSID001031872
Chemical and physical data
Formula	C₂₁H₁₁F₆N₅
Molar mass	447.344 g·mol
3D model (JSmol)	Interactive image
SMILES C1=CC(=CC=C1C2=NC3=C(C=NN3C(=C2)C(F)(F)F)C#CC4=CN=C(C=C4)N)C(F)(F)F
InChI InChI=1S/C21H11F6N5/c22-20(23,24)15-6-4-13(5-7-15)16-9-17(21(25,26)27)32-19(31-16)14(11-30-32)3-1-12-2-8-18(28)29-10-12/h2,4-11H,(H2,28,29) Key:DMJHZVARRXJSEG-UHFFFAOYSA-N

Decoglurant (INN) (code name RG1578, RO4995819) is a negative allosteric modulator of the mGlu₂ and mGlu₃ receptors which was under development by Roche for the adjunctive treatment of major depressive disorder. Decoglurant progressed as far as phase II clinical trials but was ultimately discontinued from further development due to disappointing efficacy results.

References

^ "Roche – Pipeline". 2014. Archived from the original on 2022-10-23. Retrieved 2014-08-01.
^ "Roche Group Development Pipeline" (PDF). 2014. Archived from the original (PDF) on 2014-08-08. Retrieved 2014-08-01.
"Roche – Pipeline" (PDF). 2015. Archived from the original (PDF) on 2015-05-01. Retrieved 2015-05-14.
Lawrence J (March 2015). "The Secret Life of ketamine". The Pharmaceutical Journal. 294 (7854/5).

mGluR₁Tooltip Metabotropic glutamate receptor 1

mGluR₅Tooltip Metabotropic glutamate receptor 5

mGluR₂Tooltip Metabotropic glutamate receptor 2

mGluR₃Tooltip Metabotropic glutamate receptor 3

mGluR₄Tooltip Metabotropic glutamate receptor 4	Agonists: Glutamate L-AP4 LSP2-9166 PHCCC VU-001,171 VU-0155,041; Positive allosteric modulators: Foliglurax MPEP Antagonists: CPPG MAP4 MPPG MSOP MTPG UBP-1112
mGluR₆Tooltip Metabotropic glutamate receptor 6	Agonists: Glutamate L-AP4 Antagonists: CPPG MAP4 MPPG MSOP MTPG UBP-1112
mGluR₇Tooltip Metabotropic glutamate receptor 7	Agonists: AMN082 Glutamate L-AP4 LSP2-9166 Antagonists: CPPG MAP4 MMPIP MPPG MSOP MTPG UBP-1112 XAP044; Negative allosteric modulators: ADX71743
mGluR₈Tooltip Metabotropic glutamate receptor 8	Agonists: DCPG Glutamate L-AP4; Positive allosteric modulators: AZ12216052 Antagonists: CPPG MAP4 MPPG MSOP MTPG UBP-1112

See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators

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