Misplaced Pages

LY-307,452

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Chemical compound Pharmaceutical compound
LY-307,452
Identifiers
IUPAC name
  • (2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)pentan-1,5-dioic acid
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC21H25NO4
Molar mass355.434 g·mol
3D model (JSmol)
SMILES
  • C1=CC=C(C=C1)C(CCC(C(C(=O)O)N)C(=O)O)C2=CC=CC=C2
InChI
  • InChI=1S/C21H25NO4/c22-19(21(25)26)14-17(20(23)24)12-7-13-18(15-8-3-1-4-9-15)16-10-5-2-6-11-16/h1-6,8-11,17-19H,7,12-14,22H2,(H,23,24)(H,25,26)/t17-,19-/m0/s1
  • Key:DWLOVDOPFJPWNE-HKUYNNGSSA-N
  (what is this?)  (verify)

LY-307,452 is a drug used in neuroscience research, which was among the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), and was useful in early studies of this receptor family, although it has largely been replaced by newer drugs such as LY-341,495. Its molecular formula is C21H25NO4

References

  1. Wermuth CG, Mann A, Schoenfelder A, Wright RA, Johnson BG, Burnett JP, Mayne NG, Schoepp DD (February 1996). "(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase". Journal of Medicinal Chemistry. 39 (4): 814–6. doi:10.1021/jm9508144. PMID 8632404.
  2. Li XC, Beart PM, Monn JA, Jones NM, Widdop RE (October 1999). "Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats". British Journal of Pharmacology. 128 (3): 823–9. doi:10.1038/sj.bjp.0702850. PMC 1571690. PMID 10516668.
  3. Sung KW, Choi S, Lovinger DM (November 2001). "Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses". Journal of Neurophysiology. 86 (5): 2405–12. doi:10.1152/jn.2001.86.5.2405. PMID 11698530. S2CID 15299425.
  4. "LY-307,452 | C21H25NO4 | ChemSpider".
Metabotropic glutamate receptor modulators
Group I
mGluR1Tooltip Metabotropic glutamate receptor 1
mGluR5Tooltip Metabotropic glutamate receptor 5
Group II
mGluR2Tooltip Metabotropic glutamate receptor 2
mGluR3Tooltip Metabotropic glutamate receptor 3
Group III
mGluR4Tooltip Metabotropic glutamate receptor 4
mGluR6Tooltip Metabotropic glutamate receptor 6
mGluR7Tooltip Metabotropic glutamate receptor 7
mGluR8Tooltip Metabotropic glutamate receptor 8
See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators
Stub icon

This drug article relating to the nervous system is a stub. You can help Misplaced Pages by expanding it.

Categories: