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| IUPAC name N-Propan-2-yl-5-(2-pyridin-4-ylethynyl)pyridine-2-carboxamide | |
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| Properties | |
| Chemical formula | C16H15N3O |
| Molar mass | 265.316 g·mol |
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| Signal word | Warning |
| Hazard statements | H302, H315, H319, H335 |
| Precautionary statements | P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, P501 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references | |
LSN2463359 is a drug used in scientific research.
Mechanism of action
LSN2463359 is a positive allosteric modulator of the mGluR5, which means it increases the activity of glutamate (an excitatory neurotransmitter) at this receptor.
Potential uses
A study has found that LSN2463359 and similar drugs can be used as a treatment to some aspects of cognitive deficits in schizophrenia. Another study also mention that it could be used in the treatment of schizophrenia due to the potential interactions between NMDA receptors and mGluR5.
References
- "N-Isopropyl-5-(pyridin-4-ylethynyl)picolinamide". pubchem.ncbi.nlm.nih.gov.
- Gilmour, Gary; Broad, Lisa M.; Wafford, Keith A.; Britton, Thomas; Colvin, Ellen M.; Fivush, Adam; Gastambide, Francois; Getman, Brian; Heinz, Beverly A.; McCarthy, Andrew P.; Prieto, Lourdes; Shanks, Elaine; Smith, Janice W.; Taboada, Lorena; Edgar, Dale M. (January 2013). "In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat". Neuropharmacology. 64: 224–239. doi:10.1016/j.neuropharm.2012.07.030. ISSN 1873-7064. PMID 22884720.
- Gastambide, Francois; Cotel, Marie-Caroline; Gilmour, Gary; O'Neill, Michael J.; Robbins, Trevor W.; Tricklebank, Mark D. (March 2012). "Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator". Neuropsychopharmacology. 37 (4): 1057–1066. doi:10.1038/npp.2011.298. ISSN 1740-634X. PMC 3280638. PMID 22129780.
- Gastambide, Francois; Gilmour, Gary; Robbins, Trevor W.; Tricklebank, Mark D. (January 2013). "The mGlu₅ positive allosteric modulator LSN2463359 differentially modulates motor, instrumental and cognitive effects of NMDA receptor antagonists in the rat". Neuropharmacology. 64: 240–247. doi:10.1016/j.neuropharm.2012.07.039. ISSN 1873-7064. PMID 22884612.