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ADGRG7
Identifiers
Aliases	ADGRG7, GPR128, adhesion G protein-coupled receptor G7
External IDs	OMIM: 612307; MGI: 2441732; HomoloGene: 13115; GeneCards: ADGRG7; OMA:ADGRG7 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q12.2 Start 100,609,601 bp End 100,695,479 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C1.1 Start 56,544,972 bp End 56,616,218 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum testicle right lobe of liver mucosa of transverse colon gonad rectum gallbladder smooth muscle tissue appendix Top expressed in jejunum ileum colon duodenum spermatid uterus yolk sac ovary embryo granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity protein binding transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane membrane intracellular anatomical structure integral component of plasma membrane Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84873 239853 Ensembl ENSG00000144820 ENSMUSG00000022755 UniProt Q96K78 Q8BM96 RefSeq (mRNA) NM_001308362 NM_032787 NM_172825 RefSeq (protein) NP_001295291 NP_116176 NP_766413 Location (UCSC) Chr 3: 100.61 – 100.7 Mb Chr 16: 56.54 – 56.62 Mb PubMed search
Wikidata
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G protein-coupled receptor 128 is a protein encoded by the ADGRG7 gene. GPR128 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Tissue distribution

GPR128 is specifically expressed in human liver as well as in mouse bone marrow and intestinal tissues.

Function

Ni et al. showed that Gpr128 deletion in mice causes reduced body weight and induced intestinal contraction frequency.

Clinical significance

A 111-kb copy number gain with breakpoints within the TRK-fused gene (a target of translocations in lymphoma and thyroid tumors) and GPR128 has been identified in the genome of patients with atypical myeloproliferative neoplasms. Notably, the fused gene was also detected in few healthy individuals.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000144820 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022755 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPR128 G protein-coupled receptor 128".
6. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. Bibcode:2002FEBSL.531..407F. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
7. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
8. Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
9. Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
10. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
11. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
12. Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL, et al. (January 2014). "Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency". World Journal of Gastroenterology. 20 (2): 498–508. doi:10.3748/wjg.v20.i2.498. PMC 3923024. PMID 24574718.
13. Chase A, Ernst T, Fiebig A, Collins A, Grand F, Erben P, et al. (January 2010). "TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals". Haematologica. 95 (1): 20–26. doi:10.3324/haematol.2009.011536. PMC 2805730. PMID 19797732.

External links

• Adhesion GPCR consortium

• Genes on human chromosome 3
• G protein-coupled receptors