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CX157: Difference between revisions

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Revision as of 12:57, 11 February 2012 edit86.135.115.218 (talk) this is a trademark (what is the generic name?)← Previous edit Latest revision as of 00:11, 5 November 2022 edit undoEntranced98 (talk | contribs)Extended confirmed users, Pending changes reviewers, Rollbackers173,243 edits +sd 
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{{short description|Chemical compound}}
{{Drugbox {{Drugbox
| verifiedrevid = 396516252 | verifiedrevid = 396516252
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<!--Identifiers--> <!--Identifiers-->
| CAS_number = | CAS_number = 205187-53-7
| CAS_number_Ref = {{cascite|correct|CAS}}
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = O6L62LZJ0Q
| ATC_prefix = none | ATC_prefix = none
| ATC_suffix = | ATC_suffix =
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<!--Chemical data--> <!--Chemical data-->
| C = 14 | H = 8 | F = 4 | O = 4 | S = 1
| chemical_formula = C<sub>14</sub>H<sub>8</sub>F<sub>4</sub>O<sub>4</sub>S

| molecular_weight = 348.27 g/mol
| smiles = FC(F)(F)COc2cc3Oc1cc(F)ccc1S(=O)(=O)c3cc2 | smiles = FC(F)(F)COc2cc3Oc1cc(F)ccc1S(=O)(=O)c3cc2
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
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}} }}


'''Tyrima'''&trade; ('''CX157''') is a ] and ] (RIMA).<ref>{{cite conference |author=Fielding R, Mielach F, Free J, Pande A |title=Pharmacokinetics and oral bioavailability of CX157, a reversible selective MAO-A inhibitor, in primates |year=2007 |conference=2007 AAPS Annual Meeting & Exposition |url=http://www.aapsj.org/abstracts/AM_2007/AAPS2007-001233.PDF |accessdate=2009-06-14}}</ref> It is currently in phase II ]s for the treatment of ].<ref>{{ClinicalTrialsGov|NCT00739908}}</ref> '''CX157''' (proposed trade name '''TriRima''', formerly '''Tyrima''') is a ] and ] (RIMA).<ref>{{cite conference |vauthors=Fielding R, Mielach F, Free J, Pande A |title=Pharmacokinetics and oral bioavailability of CX157, a reversible selective MAO-A inhibitor, in primates |year=2007 |conference=2007 AAPS Annual Meeting & Exposition |url=http://www.aapsj.org/abstracts/AM_2007/AAPS2007-001233.PDF |accessdate=2009-06-14 |archive-url=https://web.archive.org/web/20110526192425/http://www.aapsj.org/abstracts/AM_2007/AAPS2007-001233.PDF |archive-date=2011-05-26 |url-status=dead }}</ref> As of 2007 it was in ] ]s for the treatment of ].<ref>{{ClinicalTrialsGov|NCT00739908}|A Study of CX157 (TriRima) for the Treatment of Depression (CX157-200)}}</ref> In 2013, work on the drug was terminated.

== See also ==
⚫ * ] (RIMA)
* ] (MAOI)


== References == ==References==
{{Reflist|2}} {{Reflist|2}}




{{Monoamine metabolism modulators}}
{{Antidepressants}}
{{Anxiolytics}}
{{Adrenergics}}
{{Dopaminergics}}
{{Serotonergics}}


⚫ ]
] ]
]
]
]
]
]




Latest revision as of 00:11, 5 November 2022

Chemical compound Pharmaceutical compound
CX157
Clinical data
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
IUPAC name
  • 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiine 10,10-dioxide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H8F4O4S
Molar mass348.27 g·mol
3D model (JSmol)
SMILES
  • FC(F)(F)COc2cc3Oc1cc(F)ccc1S(=O)(=O)c3cc2
InChI
  • InChI=1S/C14H8F4O4S/c15-8-1-3-12-10(5-8)22-11-6-9(21-7-14(16,17)18)2-4-13(11)23(12,19)20/h1-6H,7H2
  • Key:PDIMOTRDGUQMNY-UHFFFAOYSA-N
  (verify)

CX157 (proposed trade name TriRima, formerly Tyrima) is a selective and reversible inhibitor of MAO-A (RIMA). As of 2007 it was in phase II clinical trials for the treatment of depression. In 2013, work on the drug was terminated.

References

  1. Fielding R, Mielach F, Free J, Pande A (2007). Pharmacokinetics and oral bioavailability of CX157, a reversible selective MAO-A inhibitor, in primates (PDF). 2007 AAPS Annual Meeting & Exposition. Archived from the original (PDF) on 2011-05-26. Retrieved 2009-06-14.
  2. Clinical trial number NCT00739908} for "A Study of CX157 (TriRima) for the Treatment of Depression (CX157-200)" at ClinicalTrials.gov


Monoamine metabolism modulators
Non-specific
AAADTooltip Aromatic L-amino acid decarboxylase
MAOTooltip Monoamine oxidase
Phenethylamines
(dopamine, epinephrine,
norepinephrine)
PAHTooltip Phenylalanine hydroxylase
THTooltip Tyrosine hydroxylase
DBHTooltip Dopamine beta-hydroxylase
PNMTTooltip Phenylethanolamine N-methyltransferase
COMTTooltip Catechol-O-methyl transferase
Tryptamines
(serotonin, melatonin)
TPHTooltip Tryptophan hydroxylase
AANATTooltip Serotonin N-acetyl transferase
ASMTTooltip Acetylserotonin O-methyltransferase
Histamine
HDCTooltip Histidine decarboxylase
HNMTTooltip Histamine N-methyltransferase
DAOTooltip Diamine oxidase
See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine neurotoxins


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