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'''AM-1248''' is a drug which acts as a moderately potent ] for both the ]s ] and ], but with some dispute between sources over its exact potency and selectivity.<!-- although note Ki values often cannot be compared directly between literature sources if the assay conditions are different --> Replacing the 3-(1-naphthoyl) group found in many indole derived cannabinoid ligands, with an ]] group, generally confers significant CB<sub>2</sub> selectivity,<ref>{{Cite doi|10.1021/jm901214q}}</ref> but reasonable CB<sub>1</sub> affinity and selectivity is retained when an N-methylpiperidin-2-ylmethyl substitution is used at the indole 1-position.<ref name="US 7820144">{{Ref patent2 | country = US | number = 7820144 | status = granted | title = Receptor selective cannabimimetic aminoalkylindoles | pubdate = 2007-01-05 | gdate = 2010-10-26 | pridate= | inventor = Makriyannis A, Deng H | assign1= }}</ref><ref name="WO 2001 28557 A1">{{Ref patent2 | country = WO | number = 200128557 | status = granted | title = Cannabimimetic indole derivatives | pubdate = 2001-04-26 | gdate = 2001-06-07 | pridate= 1999-10-18 | inventor = Makriyannis A, Deng H | assign1= }}</ref> The related compound 1-pentyl-3-(1-adamantoyl)indole was identified as having been sold as a ] ] in Hungary in 2011, along with another synthetic cannabinoid ].<ref name="pmid21813254">{{cite journal |author=Jankovics P, Váradi A, Tölgyesi L, Lohner S, Németh-Palotás J, Balla J |title=Detection and identification of the new potential synthetic cannabinoids 1-pentyl-3-(2-iodobenzoyl)indole and 1-pentyl-3-(1-adamantoyl)indole in seized bulk powders in Hungary |journal=Forensic Science International |volume= |issue= |pages= |year=2011 |month=August |pmid=21813254 |doi=10.1016/j.forsciint.2011.07.011 |url=}}</ref> |
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'''AM-1248''' is a drug which acts as a moderately potent ] for both the ]s ] and ], but with some dispute between sources over its exact potency and selectivity.<!-- although note Ki values often cannot be compared directly between literature sources if the assay conditions are different --> Replacing the 3-(1-naphthoyl) group found in many indole derived cannabinoid ligands, with an ]] group, generally confers significant CB<sub>2</sub> selectivity,<ref>{{Cite doi|10.1021/jm901214q}}</ref> but reasonable CB<sub>1</sub> affinity and selectivity is retained when an N-methylpiperidin-2-ylmethyl substitution is used at the indole 1-position.<ref name="US 7820144">{{Ref patent2 | country = US | number = 7820144 | status = granted | title = Receptor selective cannabimimetic aminoalkylindoles | pubdate = 2007-01-05 | gdate = 2010-10-26 | pridate= | inventor = Makriyannis A, Deng H | assign1= }}</ref><ref name="WO 2001 28557 A1">{{Ref patent2 | country = WO | number = 200128557 | status = granted | title = Cannabimimetic indole derivatives | pubdate = 2001-04-26 | gdate = 2001-06-07 | pridate= 1999-10-18 | inventor = Makriyannis A, Deng H | assign1= }}</ref> The related compound ] was identified as having been sold as a ] ] in Hungary in 2011, along with another synthetic cannabinoid ].<ref name="pmid21813254">{{cite journal |author=Jankovics P, Váradi A, Tölgyesi L, Lohner S, Németh-Palotás J, Balla J |title=Detection and identification of the new potential synthetic cannabinoids 1-pentyl-3-(2-iodobenzoyl)indole and 1-pentyl-3-(1-adamantoyl)indole in seized bulk powders in Hungary |journal=Forensic Science International |volume= |issue= |pages= |year=2011 |month=August |pmid=21813254 |doi=10.1016/j.forsciint.2011.07.011 |url=}}</ref> |
