Not to be confused with 17α-Dihydroequilin, 17β-Dihydroequilin, or 17α-Dihydroequilenin. Pharmaceutical compound
Clinical data | |
---|---|
Other names | β-Dihydroequilenin; Δ-17β-Estradiol; 6,8-Didehydro-17β-estradiol; Estra-1,3,5(10),6,8-pentaen-3,17β-diol |
Routes of administration | By mouth |
Drug class | Estrogen |
Identifiers | |
IUPAC name
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
ChEMBL | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C18H20O2 |
Molar mass | 268.356 g·mol |
3D model (JSmol) | |
SMILES
| |
InChI
|
17β-Dihydroequilenin, or β-dihydroequilenin, also known as δ-17β-estradiol or 6,8-didehydro-17β-estradiol, as well as estra-1,3,5(10),6,8-pentaen-3,17β-diol, is a naturally occurring steroidal estrogen found in horses which is closely related to equilin, equilenin, and estradiol, and, as the 3-sulfate ester sodium salt, is a minor constituent (0.5%) of conjugated estrogens (Premarin). 17β-Dihydroequilenin has unexpectedly shown a selective estrogen receptor modulator (SERM)-like profile of estrogenic activity in studies with monkeys, in which beneficial effects on bone and the cardiovascular system were noted but proliferative responses in breast and endometrium were not observed.
See also
References
- Fritz MA, Speroff L (28 March 2012). "Postmenopausal Hormone Therapy". Clinical Gynecologic Endocrinology and Infertility. Lippincott Williams & Wilkins. pp. 751–. ISBN 978-1-4511-4847-3.
- Cline JM (April 2007). "Assessing the mammary gland of nonhuman primates: effects of endogenous hormones and exogenous hormonal agents and growth factors". Birth Defects Research. Part B, Developmental and Reproductive Toxicology. 80 (2): 126–146. doi:10.1002/bdrb.20112. PMID 17443713.
Estrogen receptor modulators | |||||||
---|---|---|---|---|---|---|---|
ERTooltip Estrogen receptor |
| ||||||
GPERTooltip G protein-coupled estrogen receptor |
| ||||||
This article about a steroid is a stub. You can help Misplaced Pages by expanding it. |
This drug article relating to the genito-urinary system is a stub. You can help Misplaced Pages by expanding it. |