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Phenestrol

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Chemical compound Pharmaceutical compound
Phenestrol
Clinical data
Other namesFenestrol; NSC-183736; hexestrol bisphenylacetate
Identifiers
IUPAC name
  • phenyl]acetyl]oxyphenyl]hexan-3-yl]phenyl] 2-phenyl]acetate
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC42H48Cl4N2O4
Molar mass786.66 g·mol
3D model (JSmol)
SMILES
  • CCC(C1=CC=C(C=C1)OC(=O)CC2=CC=C(C=C2)N(CCCl)CCCl)C(CC)C3=CC=C(C=C3)OC(=O)CC4=CC=C(C=C4)N(CCCl)CCCl
InChI
  • InChI=1S/C42H48Cl4N2O4/c1-3-39(33-9-17-37(18-10-33)51-41(49)29-31-5-13-35(14-6-31)47(25-21-43)26-22-44)40(4-2)34-11-19-38(20-12-34)52-42(50)30-32-7-15-36(16-8-32)48(27-23-45)28-24-46/h5-20,39-40H,3-4,21-30H2,1-2H3
  • Key:GTWGWCYJKHSRHO-UHFFFAOYSA-N
Not to be confused with Fenestrel.

Phenestrol, or fenestrol, also known as hexestrol bisphenylacetate, is a synthetic, nonsteroidal estrogen and cytostatic antineoplastic agent (i.e., chemotherapy drug) and a chlorphenacyl nitrogen mustard ester of hexestrol which was developed in the early 1960s for the treatment of hormone-dependent tumors but was never marketed.

See also

References

  1. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 163–. ISBN 978-1-4757-2085-3.
  2. National Cancer Institute (U.S.), Onkologicheskiĭ nauchnyĭ t͡sentr (Akademii͡a medit͡sinskikh nauk SSSR) (1981). Goldin A (ed.). Experimental evaluation of antitumor drugs in the USA and USSR and clinical correlations. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute. p. 17.
  3. Morozova TM, Merkulova TI, Martynov V, Iaguzhinskaia VP, Shkodinskaia EN (1984). "". Eksperimental'naia Onkologiia (in Russian). 6 (2): 50–54. PMID 6510335.
  4. Lagova ND, Sof'ina ZP, Shkodinskaia EN, Kurdiumova KN, Valueva IM (1988). "". Voprosy Onkologii (in Russian). 34 (11): 1363–1368. PMID 3201773.
Estrogen receptor modulators
ERTooltip Estrogen receptor
Agonists
Mixed
(SERMsTooltip Selective estrogen receptor modulators)
Antagonists
  • Coregulator-binding modulators: ERX-11
GPERTooltip G protein-coupled estrogen receptor
Agonists
Antagonists
Unknown
See also
Receptor/signaling modulators
Estrogens and antiestrogens
Androgen receptor modulators
Progesterone receptor modulators
List of estrogens
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