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ICI-85966

Clinical data
Other names	Stilbostat; Diethylstilbestrol (DES) bis(di(2-chloroethyl)carbamate)
Identifiers
IUPAC name phenyl]hex-3-en-3-yl]phenyl] N,N-bis(2-chloroethyl)carbamate
CAS Number	15470-58-3
PubChem CID	3037081
ChemSpider	2300916
UNII	VUD64CLJ7Z
CompTox Dashboard (EPA)	DTXSID301046846
Chemical and physical data
Formula	C28H34Cl4N2O4
Molar mass	604.39 g·mol
3D model (JSmol)	Interactive image
SMILES CC/C(=C(/CC)\C1=CC=C(C=C1)OC(=O)N(CCCl)CCCl)/C2=CC=C(C=C2)OC(=O)N(CCCl)CCCl
InChI InChI=1S/C28H34Cl4N2O4/c1-3-25(21-5-9-23(10-6-21)37-27(35)33(17-13-29)18-14-30)26(4-2)22-7-11-24(12-8-22)38-28(36)34(19-15-31)20-16-32/h5-12H,3-4,13-20H2,1-2H3/b26-25+ Key:BOIZOYRDXIYMCY-OCEACIFDSA-N

ICI-85966 (former tentative brand name Stilbostat), also known as diethylstilbestrol (DES) bis(di(2-chloroethyl)carbamate), is a synthetic, nonsteroidal estrogen and cytostatic antineoplastic agent of the stilbestrol group and a nitrogen mustard ester of diethylstilbestrol (DES) which was developed for the treatment of breast cancer and prostate cancer but was never marketed (possibly due to the toxicity of DES).

See also

• List of hormonal cytostatic antineoplastic agents
• List of estrogen esters

References

1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 397. ISBN 978-1-4757-2085-3.
2. Zimel H, Broder D, Zimel A (1973). "". Stud Cercet Endocrinol (in Romanian). 24 (3): 211–9. PMID 4703920.
3. Görlich M, Heise E (1976). "Contribution to the mechanism of Stilbostat action". Neoplasma. 23 (4): 363–9. PMID 1004653.
4. Zimel H, Mogos I, Maltezeanu G (1977). "Estimation of StilbostatR treatment efficiency in breast cancer by thermography". Neoplasma. 24 (5): 553–7. PMID 927612.
5. Zimel H, Bocancea D (1974). "Treatment of prostatic carcinoma with Stilbostat". Neoplasma. 21 (1): 101–8. PMID 4596007.

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• Abandoned drugs
• Antineoplastic drugs
• Estrogen esters
• Hormonal antineoplastic drugs
• Carbamates
• Synthetic estrogens
• Chloroethyl compounds
• Antineoplastic and immunomodulating drug stubs
• Genito-urinary system drug stubs