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Cod-THC

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Synthetic chemical compound Pharmaceutical compound
Cod-THC
Identifiers
IUPAC name
  • isoquinolin-7-yl] chromen-1-yl] carbonate
Chemical and physical data
FormulaC40H49NO6
Molar mass639.833 g·mol
3D model (JSmol)
SMILES
  • CN1CC23c4c5C12C=C(OC(=O)Oc1cc(CCCCC)cc2OC(C)(C)6CCC(C)=C6c21)3Oc4c(OC)cc5
InChI
  • InChI=InChI=1S/C40H49NO6/c1-7-8-9-10-24-20-32(34-26-19-23(2)11-13-27(26)39(3,4)47-33(34)21-24)45-38(42)44-31-16-14-28-29-22-25-12-15-30(43-6)36-35(25)40(28,37(31)46-36)17-18-41(29)5/h12,14-16,19-21,26-29,31,37H,7-11,13,17-18,22H2,1-6H3/t26-,27-,28+,29-,31+,37+,40+/m1/s1
  • Key:VDTVNOCXWSYPQX-IWHNUUHWSA-N

Cod-THC (Codeine Δ-tetrahydrocannabinol carbonate) is a synthetic codrug formed by linking tetrahydrocannabinol with codeine via a carbonate bridge. It is well absorbed orally and shows superior analgesic effects in animal studies compared to a simple mixture of the two drugs.

See also

References

  1. Banerjee A, Hayward JJ, Trant JF (May 2023). ""Breaking bud": the effect of direct chemical modifications of phytocannabinoids on their bioavailability, physiological effects, and therapeutic potential". Organic & Biomolecular Chemistry. 21 (18): 3715–3732. doi:10.1039/d3ob00068k. PMID 36825573. S2CID 256792029.
  2. US 2008/0176885, Holtman JR, Crooks PA, Dhooper HK, "Novel synergistic opioid-cannabinoid codrug for pain management.", published 24 July 2008, assigned to University of Kentucky and Insys Therapeutics Inc. 
  3. Crooks PA, Dhooper HK, Chakraborty U (2011). "Improving the Use of Drug Combination through the Codrug Approach". In Rautio J (ed.). Prodrugs and Targeted Delivery: Towards Better ADME Properties. Wiley. pp. 345–383 (374–376). ISBN 978-3-527-63318-0.
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