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Hexahydrocannabihexol

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Semi-synthetic cannabinoid derivative drug

Pharmaceutical compound
Hexahydrocannabihexol
Identifiers
IUPAC name
  • (6aR,10aR)-6,6,9-trimethyl-3-hexyl-6a,7,8,9,10,10a-hexahydrobenzochromen-1-ol
Chemical and physical data
FormulaC22H34O2
Molar mass330.512 g·mol
3D model (JSmol)
SMILES
  • CCCCCCc1cc2OC(C)(C)3CCC(C)C3c2c(O)c1
InChI
  • InChI=InChI=1S/C22H34O2/c1-5-6-7-8-9-16-13-19(23)21-17-12-15(2)10-11-18(17)22(3,4)24-20(21)14-16/h13-15,17-18,23H,5-12H2,1-4H3/t15?,17-,18-/m1/s1
  • Key:OKXUDFJPZMVBEH-HSFDIDPMSA-N

Hexahydrocannabihexol (HHCH) is a semi-synthetic cannabinoid derivative. It was first synthesised by Roger Adams in 1942 and found to be more potent than either the pentyl or heptyl homologues, or the unsaturated tetrahydrocannabinol analogue. HHCH was first identified as a designer drug in Sweden in September 2023.

Legality

HHCH is classified as an "intoxicating cannabinoid" in Colorado and requires a license for its manufacture or distribution.

In Japan, after several people who had eaten gummy candies containing HHCH fell ill, this chemical was officially added to the list of designated substances. And since 2 December 2023, it has been illegal to possess, use, or sell it.

See also

References

  1. Adams R, Loewe S, Smith CM, McPhee WD (March 1942). "Tetrahydrocannabinol homologs and analogs with marihuana activity. XIII". Journal of the American Chemical Society. 64 (3): 694–697. doi:10.1021/ja01255a061.
  2. "Hexahydrocannabinol (HHC) and related substances" (PDF). European Monitoring Centre for Drugs and Drug Addiction. 2023.
  3. "New psychoactive substances - the current situation in Europe" (PDF). European Drug Report. European Union Drugs Agency (EUDA). 2024.
  4. "Senate Bill 23-271" (PDF). General Assembly, State of Colorado.
  5. "Japanese government to ban cannabis-like substance, HHCH". NHK. 2023-11-21. Retrieved 2023-11-22.
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