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THCP-O-acetate

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Chemical compound

Pharmaceutical compound
THCP-O-acetate
Identifiers
IUPAC name
  • (6aR,10aR)-3-heptyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydrobenzochromen-1-yl acetate
CAS Number
ChemSpider
Chemical and physical data
FormulaC25H36O3
Molar mass384.560 g·mol
3D model (JSmol)
SMILES
  • CC(=O)Oc1cc(CCCCCCC)cc2OC(C)(C)3CCC(C)=C3c21
InChI
  • InChI=1S/C25H36O3/c1-6-7-8-9-10-11-19-15-22(27-18(3)26)24-20-14-17(2)12-13-21(20)25(4,5)28-23(24)16-19/h14-16,20-21H,6-13H2,1-5H3/t20-,21-/m1/s1
  • Key:OXMUZNKOOOITQD-NHCUHLMSSA-N

THCP-O-acetate (THCP-O) is a semi-synthetic derivative of tetrahydrocannabiphorol (THCP) derived by acetylation of the OH group. It has been found as a component of grey-market cannabis products such as e-cigarette liquids and edible gummy lollies, and is allegedly a potent and long-lasting psychoactive cannabinoid.

Toxicity

In 2022, researchers at Portland State University who screened for the presence of reacted ketene as N-benzylacetamide reported that Vitamin E acetate, CBD-acetate, CBN-acetate and THC-O-acetate may break down to release ketene gas when heated at 340 °C (644 °F).

Legality

Japan banned THCP-O-Acetate along with HHCP on December 26, 2023.

See also

References

  1. Erickson BE (2023). "Waiting for CBD regulations in the US". Chemical & Engineering News. 101 (28): 17–19. doi:10.1021/cen-10128-feature1. S2CID 261318144.
  2. Munger KR, Jensen RP, Strongin RM (July 2022). "Vaping Cannabinoid Acetates Leads to Ketene Formation". Chemical Research in Toxicology. 35 (7): 1202–1205. doi:10.1021/acs.chemrestox.2c00170. PMID 35801872.
  3. Sagen J, Paikoff S, Ford J, Newman D, Jyot J (2022). "Proceedings of the 2022 Cannabis Clinical Outcomes Research Conference (CCORC) Orlando, FL, USA, May 19-20, 2022". Medical Cannabis and Cannabinoids. 5 (1): 142–158. doi:10.1159/000527081. PMC 9729860.
  4. "Japan bans sale of 38 goods with synthetic cannabis compounds". The Japan Times. 22 December 2023.
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