Disodium phosphate: Difference between revisions

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	\| Watchedfields = changed		\| Watchedfields = changed
	\| verifiedrevid = 457118728		\| verifiedrevid = 457118728
	\|ImageFile = Disodium hydrogen phosphate.png		\| ImageFile = Disodium hydrogen phosphate.png
	\| ImageSize = 150px		\| ImageSize = 150px
	\| ~~IUPACName~~ = ~~Sodium~~ ~~hydrogen~~ phosphate		\| ImageAlt = Structural formula of disodium phosphate
			\| ImageFile1 = Disodium phosphate 3D spacefill.png
⚫	\| OtherNames = Disodium hydrogen orthophosphate~~<br/>Sodium~~ hydrogen phosphate~~<br/>Sodium~~ phosphate ~~dibasic<br/>di-~~Sodium ~~Phosphate~~
			\| ImageSize1 = 250
			\| ImageAlt1 = Ball-and-stick model of the component ions of disodium phosphate
			\| ImageCaption1 = {{legend\|purple\|], Na}}{{legend\|orange\|], P}}{{legend\|red\|], O}}{{legend\|white\|], H}}
			\| ImageFile2 = Hydrogenfosforečnan sodný dodekahydrát.jpg
			\| IUPACName = Disodium hydrogen phosphate
		⚫	\| OtherNames = {{ubl\|Acetest\|Dibasic sodium phosphate\|Disodium hydrogen orthophosphate\|Disodium hydrogen phosphate\|Disodium phosphate\|Sodium phosphate dibasic}}
			\| SystematicName =
	\| Section1 = {{Chembox Identifiers		\| Section1 = {{Chembox Identifiers
	\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}		\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}
	\| ChemSpiderID = 22625		\| ChemSpiderID = 22625
	\| UNII_Ref = {{fdacite\|correct\|FDA}}		\| UNII_Ref = {{fdacite\|correct\|FDA}}
	\| UNII = 22ADO53M6F		\| UNII = 22ADO53M6F
			\| UNII2_Ref = {{fdacite\|correct\|FDA}}
			\| UNII2 = 94255I6E2T
			\| UNII2_Comment = (dihydrate)
			\| UNII3_Ref = {{fdacite\|correct\|FDA}}
			\| UNII3 = 70WT22SF4B
			\| UNII3_Comment = (heptahydrate)
			\| UNII4_Ref = {{fdacite\|correct\|FDA}}
			\| UNII4 = E1W4N241FO
			\| UNII4_Comment = (dodecahydrate)
	\| InChI = 1/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-3		\| InChI = 1/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-3
	\| ChEMBL_Ref = {{ebicite\|correct\|EBI}}		\| ChEMBL_Ref = {{ebicite\|correct\|EBI}}
Line 17:		Line 33:
	\| ChEBI_Ref = {{ebicite\|correct\|EBI}}		\| ChEBI_Ref = {{ebicite\|correct\|EBI}}
	\| ChEBI = 34683		\| ChEBI = 34683
	\| SMILES = ~~..P~~()(~~)=O~~		\| SMILES = OP(=O)()..
	\| InChIKey = BNIILDVGGAEEIG-DFZHHIFOAK		\| InChIKey = BNIILDVGGAEEIG-DFZHHIFOAK
	\| StdInChI_Ref = {{stdinchicite\|changed\|chemspider}}		\| StdInChI_Ref = {{stdinchicite\|changed\|chemspider}}
Line 24:		Line 40:
	\| StdInChIKey_Ref = {{stdinchicite\|changed\|chemspider}}		\| StdInChIKey_Ref = {{stdinchicite\|changed\|chemspider}}
	\| CASNo = 7558-79-4		\| CASNo = 7558-79-4
	\| CASNo_Ref = {{cascite\|correct\|CAS}}		\| CASNo_Ref = {{cascite\|correct\|CAS}}
			\| CASNo2_Ref = {{cascite\|correct\|CAS}}
	\| CASOther = <br/>10028-24-7 (dihydrate)<br/>7782-85-6 (heptahydrate)<br/>10039-32-4 (dodecahydrate)
	\| ~~PubChem~~ = ~~24203~~		\| CASNo2 = 10028-24-7
			\| CASNo2_Comment = (dihydrate)
⚫	\| EINECS = 231-448-7
			\| CASNo3_Ref = {{cascite\|correct\|CAS}}
⚫	\| RTECS = WC4500000
			\| CASNo3 = 7782-85-6
	}}
			\| CASNo3_Comment = (heptahydrate)
			\| CASNo4_Ref = {{cascite\|correct\|CAS}}
			\| CASNo4 = 10039-32-4
			\| CASNo4_Comment = (dodecahydrate)
			\| PubChem = 24203
		⚫	\| EINECS = 231-448-7
		⚫	\| RTECS = WC4500000
		⚫	}}
	\| Section2 = {{Chembox Properties		\| Section2 = {{Chembox Properties
	\| Formula = ~~Na<sub>2</sub>HPO<sub>4</sub>~~		\| Formula = {{chem2\|Na2HPO4}}
	\| MolarMass = 141.96 g/mol (anhydrous)~~<br~~/>268.07 g/mol (heptahydrate)		\| MolarMass = {{ubl\|141.96 g/mol (anhydrous)\|177.99 g/mol (dihydrate)\|268.07 g/mol (heptahydrate)}}
	\| Appearance = White crystalline solid		\| Appearance = White crystalline solid
			\| RefractIndex = 1.35644 to 1.35717 at 20°C
	\| Odor = odorless
	\| Density = 1.7 g/cm<sup>3</sup>		\| Odor = Odorless
			\| Density = 1.7 g/cm<sup>3</sup>
	\| ~~MeltingPt~~ = 250 ~~ºC decomp.~~		\| MeltingPtC = 250
			\| MeltingPt_notes = Decomposes
	\| Solubility = 7.7 g/100 ml (20 ºC) <br> 11.8 g/100 mL (25 °C, heptahydrate)		\| Solubility = 7.7 g/(100 ml) (20 °C)<br>11.8 g/(100 ml) (25 °C, heptahydrate)
⚫	\| pKa = 12.35
			\| SolubleOther = Insoluble in ]
⚫	}}
		⚫	\| pKa = 12.35
			\| LogP = −5.8
			\| MagSus = −56.6·10<sup>−6</sup> cm<sup>3</sup>/mol
			}}
			\| Section3 =
			\| Section4 =
			\| Section5 =
			\| Section6 =
	\| Section7 = {{Chembox Hazards		\| Section7 = {{Chembox Hazards
	\| ~~ExternalMSDS~~ =		\| ExternalSDS =
	\| ~~EUIndex~~ = ~~Not listed~~		\| NFPA-H = 1
	\| NFPA-H = 1		\| NFPA-F = 0
	\| NFPA-F = 0		\| NFPA-R = 0
	\| ~~NFPA-R~~ = 0		\| MainHazards = Irritant
		⚫	\| FlashPt = Non-flammable
	\| MainHazards = Irritant
			\| LD50 = 17000 mg/kg (rat, oral)
⚫	\| FlashPt = Non-flammable
	}}		}}
	\| Section8 = {{Chembox Related		\| Section8 = {{Chembox Related
	\| OtherAnions = ]		\| OtherAnions = ]
	\| OtherCations = ]<br/>]		\| OtherCations = ]<br/>]
	\| ~~OtherCpds~~ = ]<br/>]		\| OtherCompounds = ]<br/>]
	}}		}}
	}}		}}

	'''Disodium ~~hydrogen~~ phosphate''' (~~Na<sub>2</sub>HPO<sub>4</sub>~~) is a ] ] of ]. It is a white ~~powder~~ ~~that~~ is ~~highly~~ ] ~~and water soluble~~.<ref> ~~</ref> It is~~ ~~therefore~~ ~~used commercially as an anti~~-~~caking additive in powdered products~~. ~~It is also known as disodium hydrogen orthophosphate, sodium hydrogen phosphate or sodium phosphate dibasic~~. ~~It is commercially available in both the hydrated and anhydrous forms.<ref>~~ </ref> ~~] of disodium hydrogen phosphate water solution is between 8.0 and 11.0, meaning it is ].~~		'''Disodium phosphate''' ('''DSP'''), or '''disodium hydrogen phosphate''', or '''sodium phosphate dibasic''', is an ] with the ] {{chem2\|Na2HPO4\|auto=1}}. It is one of several ]. The ] is known in ] form as well as ] {{chem2\|Na2HPO4*''n''H2O}}, where ''n'' is 2, 7, 8, and 12. All are water-soluble white powders. The anhydrous salt is ].<ref>{{Cite web \|url=http://www.ffcr.or.jp/zaidan/FFCRHOME.nsf/7bd44c20b0dc562649256502001b65e9/916cae3da5a8a11b49256f320018877f/$FILE/D121.pdf \|title=Physical data (pdf) \|access-date=2007-03-06 \|archive-url=https://web.archive.org/web/20110717102830/http://www.ffcr.or.jp/zaidan/FFCRHOME.nsf/7bd44c20b0dc562649256502001b65e9/916cae3da5a8a11b49256f320018877f/$FILE/D121.pdf \|archive-date=2011-07-17 \|url-status=dead}}</ref>
	==Other uses==
	*Disodium phosphate is used in ] to quicken cook time, and Jell-O Instant Pudding for thickening, as described on the ingredients panel of the product package.
	*Disodium phosphate is used in conjunction with ] in many steam-boiler applications. It supplies the inventory of free phosphates to retard calcium scale formation.
	*Monobasic and dibasic sodium phosphate is used as a to treat constipation or to clean the bowel before a colonoscopy.

			The ] of disodium hydrogen phosphate water solution is between 8.0 and 11.0, meaning it is moderately ]:
	==Manufacturing==
			:{{chem2\|HPO4(2−) + H2O ⇌ H2PO4− + OH−}}
	Disodium monophosphate is produced from ] and ].

			==Production and reactions==
⚫	== References ==
			It can be generated by neutralization of ] with ]:
			:{{chem2\|H3PO4 + 2 NaOH → Na2HPO4 + 2 H2O}}

			Industrially It is prepared in a two-step process by treating ] with ], which precipitates ]:<ref name=Ullmann>Klaus Schrödter, Gerhard Bettermann, Thomas Staffel, Friedrich Wahl, Thomas Klein, Thomas Hofmann "Phosphoric Acid and Phosphates" in ''Ullmann’s Encyclopedia of Industrial Chemistry'' 2008, Wiley-VCH, Weinheim. {{doi\|10.1002/14356007.a19_465.pub3}}</ref>
			:{{chem2\|CaHPO4 + NaHSO4 → NaH2PO4 + CaSO4}}
			In the second step, the resulting solution of monosodium phosphate is partially neutralized:
			:{{chem2\|NaH2PO4 + NaOH → Na2HPO4 + H2O}}

			==Uses==
			It is used in conjunction with ] in foods and water softening treatment. In foods, it is used to adjust pH. Its presence prevents coagulation in the preparation of condensed milk. Similarly, it is used as an anti-caking additive in powdered products.<ref>{{Cite web \|url=http://www.sciencelab.com/msds.php?msdsId=9925023 \|title=MSDS \|access-date=2011-09-26 \|archive-url=https://web.archive.org/web/20171028050920/http://www.sciencelab.com/msds.php?msdsId=9925023 \|archive-date=2017-10-28 \|url-status=dead}}</ref> It is used in desserts and puddings, e.g. ] to quicken cook time, and Jell-O ] for thickening. In water treatment, it retards ].{{Citation needed\|date=September 2021}} It is also found in some detergents and cleaning agents.<ref name=Ullmann/>

			Heating solid disodium phosphate gives the useful compound ]:{{citation needed\|date=July 2016}}
			:{{chem2\|2 Na2HPO4 → Na4P2O7 + H2O}}

			=== Laxative ===
			Monobasic and dibasic sodium phosphate are used as a ] to treat ] or to clean the bowel before a ].<ref>{{Cite web \| url = http://wishardhealth.kramesonline.com/Medications/26,1558 \| title = Sodium Phosphate, Dibasic, Sodium Phosphate, Monobasic Oral solution \| publisher = Krames Patient Education \| access-date = 2009-10-29 \| archive-url = https://archive.today/20130128005243/http://wishardhealth.kramesonline.com/Medications/26,1558 \| archive-date = 2013-01-28 \| url-status = dead}}</ref>

		⚫	==References==
	{{reflist}}		{{reflist}}

			==External links==
			*{{Commonscatinline}} solubility in Prophylaxis alcohol

	{{Sodium compounds}}		{{Sodium compounds}}
			{{Phosphates}}

	]		]
	]		]
			]

	{{inorganic-compound-stub}}

Latest revision as of 00:52, 15 May 2024

Disodium phosphate
Names

Sodium, Na Phosphorus, P Oxygen, O Hydrogen, H

IUPAC name Disodium hydrogen phosphate
Other names Acetest Dibasic sodium phosphate Disodium hydrogen orthophosphate Disodium hydrogen phosphate Disodium phosphate Sodium phosphate dibasic
Identifiers
CAS Number	7558-79-4 10028-24-7 (dihydrate) 7782-85-6 (heptahydrate) 10039-32-4 (dodecahydrate)
3D model (JSmol)	Interactive image
ChEBI	CHEBI:34683
ChEMBL	ChEMBL1060
ChemSpider	22625
ECHA InfoCard	100.028.590
EC Number	231-448-7
E number	E339(ii) (antioxidants, ...)
PubChem CID	24203
RTECS number	WC4500000
UNII	22ADO53M6F 94255I6E2T (dihydrate) 70WT22SF4B (heptahydrate) E1W4N241FO (dodecahydrate)
CompTox Dashboard (EPA)	DTXSID1026039
InChI InChI=1S/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2+1;/p-3Key: BNIILDVGGAEEIG-UHFFFAOYSA-K InChI=1/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2+1;/p-3Key: BNIILDVGGAEEIG-DFZHHIFOAK
SMILES OP(=O)()..
Properties
Chemical formula	Na₂HPO₄
Molar mass	141.96 g/mol (anhydrous) 177.99 g/mol (dihydrate) 268.07 g/mol (heptahydrate)
Appearance	White crystalline solid
Odor	Odorless
Density	1.7 g/cm
Melting point	250 °C (482 °F; 523 K) Decomposes
Solubility in water	7.7 g/(100 ml) (20 °C) 11.8 g/(100 ml) (25 °C, heptahydrate)
Solubility	Insoluble in ethanol
log P	−5.8
Acidity (pK_a)	12.35
Magnetic susceptibility (χ)	−56.6·10 cm/mol
Refractive index (n_D)	1.35644 to 1.35717 at 20°C
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	Irritant
NFPA 704 (fire diamond)	1 0 0
Flash point	Non-flammable
Lethal dose or concentration (LD, LC):
LD₅₀ (median dose)	17000 mg/kg (rat, oral)
Safety data sheet (SDS)	ICSC 1129
Related compounds
Other anions	sodium phosphite
Other cations	Dipotassium phosphate Diammonium phosphate
Related compounds	Monosodium phosphate Trisodium phosphate
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). N verify (what is ?) Infobox references

Chemical compound

Disodium phosphate (DSP), or disodium hydrogen phosphate, or sodium phosphate dibasic, is an inorganic compound with the chemical formula Na₂H P O₄. It is one of several sodium phosphates. The salt is known in anhydrous form as well as hydrates Na₂HPO₄·nH₂O, where n is 2, 7, 8, and 12. All are water-soluble white powders. The anhydrous salt is hygroscopic.

The pH of disodium hydrogen phosphate water solution is between 8.0 and 11.0, meaning it is moderately basic:

HPO2−4 + H₂O ⇌ H₂PO−4 + OH

Production and reactions

It can be generated by neutralization of phosphoric acid with sodium hydroxide:

H₃PO₄ + 2 NaOH → Na₂HPO₄ + 2 H₂O

Industrially It is prepared in a two-step process by treating dicalcium phosphate with sodium bisulfate, which precipitates calcium sulfate:

CaHPO₄ + NaHSO₄ → NaH₂PO₄ + CaSO₄

In the second step, the resulting solution of monosodium phosphate is partially neutralized:

NaH₂PO₄ + NaOH → Na₂HPO₄ + H₂O

Uses

It is used in conjunction with trisodium phosphate in foods and water softening treatment. In foods, it is used to adjust pH. Its presence prevents coagulation in the preparation of condensed milk. Similarly, it is used as an anti-caking additive in powdered products. It is used in desserts and puddings, e.g. Cream of Wheat to quicken cook time, and Jell-O Instant Pudding for thickening. In water treatment, it retards calcium scale formation. It is also found in some detergents and cleaning agents.

Heating solid disodium phosphate gives the useful compound tetrasodium pyrophosphate:

2 Na₂HPO₄ → Na₄P₂O₇ + H₂O

Laxative

Monobasic and dibasic sodium phosphate are used as a saline laxative to treat constipation or to clean the bowel before a colonoscopy.

References

"Physical data (pdf)" (PDF). Archived from the original (PDF) on 2011-07-17. Retrieved 2007-03-06.
^ Klaus Schrödter, Gerhard Bettermann, Thomas Staffel, Friedrich Wahl, Thomas Klein, Thomas Hofmann "Phosphoric Acid and Phosphates" in Ullmann’s Encyclopedia of Industrial Chemistry 2008, Wiley-VCH, Weinheim. doi:10.1002/14356007.a19_465.pub3
"MSDS". Archived from the original on 2017-10-28. Retrieved 2011-09-26.
"Sodium Phosphate, Dibasic, Sodium Phosphate, Monobasic Oral solution". Krames Patient Education. Archived from the original on 2013-01-28. Retrieved 2009-10-29.

External links

Media related to Disodium phosphate at Wikimedia Commons solubility in Prophylaxis alcohol

Sodium compounds

Inorganic

Halides	NaF NaHF₂ NaCl NaBr NaI NaAt
Chalcogenides	NaO₃ NaO₂ Na₂O Na₂O₂ NaOH NaOD Na₂S NaSH Na₂Se NaSeH Na₂Te NaHTe Na₂Po
Pnictogenides	Na₃N NaN₃ NaNH₂ Na₃P Na₃As
Oxyhalides	NaClO NaClO₂ NaClO₃ NaClO₄ NaBrO NaBrO₂ NaBrO₃ NaBrO₄ NaIO NaIO₃ NaIO₄
Oxychalcogenides	Na₂SO₃ Na₂SO₄ NaHSO₃ NaHSO₄ Na₂S₂O₃ Na₂S₂O₄ Na₂S₂O₅ Na₂S₂O₆ Na₂S₂O₇ Na₂S₂O₈ Na₂SeO₃ Na₂SeO₄ NaHSeO₃ Na₂TeO₃
Oxypnictogenides	NaNO₂ NaNO₃ Na₂N₂O₂ NaH₂PO₄ NaPO₂H₂ Na₂HPO₃ Na₂PO₃F Na₃PS₂O₂ Na₃PO₄ Na₅P₃O₁₀ Na₄P₂O₇ Na₂H₂P₂O₇ Na₃AsO₃ Na₃AsO₄ Na₂HAsO₄ NaH₂AsO₄ NaSbO₃
Others	NaAlH₄ NaAlO₂ Na₃AlF₆ NaAl(SO₄)₂ NaAuCl₄ NaSbF₆ NaAsF₆ Na₂TiF₆ NaBH₄ NaBH₃(CN) NaBO₂ Na₂B₄O₇ Na₂B₂O₉ Na₂B₈O₁₃ NaBiO₃ NaCN NaCNO NaCoO₂ NaH NaHCO₃ Na₄XeO₆ NaHXeO₄ NaMnO₄ NaOCN NaReO₄ NaSCN NaTcO₃ NaTcO₄ NaVO₃ Na₂CO₃ Na₂C₂O₄ Na₂C₃S₅ Na₂CrO₄ Na₂Cr₂O₇ Na₂Cr₃O₁₀ Na₂GeO₃ Na₂He Na₂ Na₂MnO₄ Na₂MoO₄ Na₃IrCl₆ Na₂PtCl₆ Na₂O(UO₃)₂ Na₂S₄O₆ Na₂SiO₃ Na₂TiO₃ Na₂U₂O₇ Na₂WO₄ Na₂Zn(OH)₄ Na₃VO₄ Na₆V₁₀O₂₈ Na₄Fe(CN)₆ Na₃Fe(CN)₆ Na₃Fe(C₂O₄)₃ Na₄SiO₄ Na₂SiF₆ Na₃[Co(NO₂)₆] NaNSi₂(CH₃)₆ Na₂PdCl₄