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Bazinaprine

Clinical data
ATC code	None
Identifiers
IUPAC name 3-{amino}-6-phenylpyridazine-4-carbonitrile
CAS Number	94011-82-2
PubChem CID	72119
ChemSpider	65096
UNII	NU8Y4C529J
ChEMBL	ChEMBL150365
CompTox Dashboard (EPA)	DTXSID70240219
Chemical and physical data
Formula	C17H19N5O
Molar mass	309.373 g·mol
3D model (JSmol)	Interactive image
SMILES N#Cc2cc(nnc2NCCN1CCOCC1)c3ccccc3
InChI InChI=1S/C17H19N5O/c18-13-15-12-16(14-4-2-1-3-5-14)20-21-17(15)19-6-7-22-8-10-23-11-9-22/h1-5,12H,6-11H2,(H,19,21) Key:KRNDIPHOJLIHRI-UHFFFAOYSA-N
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Bazinaprine (SR-95,191) is an experimental drug candidate. It is a monoamine oxidase inhibitor (MAOI) which is believed to be useful for the treatment of depression. The drug strongly inhibits type A monoamine oxidase, but only weakly inhibits type B. The effects of the drug are reversible in vivo, but not in vitro. In studies, the chemical has been shown to not interact in vivo with other neurotransmitter or drug receptor sites.

See also

• Reversible inhibitor of MAO-A (RIMA)

References

1. Kan JP, Steinberg R, Leclercq J, Worms P, Biziere K (April 1988). "Monoamine oxidase-inhibiting properties of SR 95191, a new pyridazine derivative, in the rat: evidence for selective and reversible inhibition of monoamine oxidase type A in vivo but not in vitro". Journal of Neurochemistry. 50 (4): 1137–44. doi:10.1111/j.1471-4159.1988.tb10584.x. PMID 3346672. S2CID 12521641.
2. Kan JP, Steinberg R, Mouget-Goniot C, Worms P, Bizière K (January 1987). "SR 95191, a selective inhibitor of type A monoamine oxidase with dopaminergic properties. II. Biochemical characterization of monoamine oxidase inhibition". The Journal of Pharmacology and Experimental Therapeutics. 240 (1): 251–8. PMID 3100771.

• Drugs not assigned an ATC code
• Monoamine oxidase inhibitors
• 4-Morpholinyl compounds
• Nitriles
• Pyridazines