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Bazinaprine

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Revision as of 21:15, 1 December 2011 by Velella (talk | contribs) (Reverted addition of dubious unsourced content (HG))(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compound
Bazinaprine
Clinical data
ATC code
  • None
Identifiers
IUPAC name
  • 3-{amino}-6-phenylpyridazine-4-carbonitrile
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H19N5O
Molar mass309.366 g/mol g·mol
3D model (JSmol)
SMILES
  • N#Cc2cc(nnc2NCCN1CCOCC1)c3ccccc3
InChI
  • InChI=1S/C17H19N5O/c18-13-15-12-16(14-4-2-1-3-5-14)20-21-17(15)19-6-7-22-8-10-23-11-9-22/h1-5,12H,6-11H2,(H,19,21)
  • Key:KRNDIPHOJLIHRI-UHFFFAOYSA-N

Bazinaprine (SR-95,191) is an experimental drug candidate. It is a monoamine oxidase inhibitor (MAOI) which is believed to be useful for the treatment of depression. The drug strongly inhibits type A monoamine oxidase, but only weakly inhibits type B. The effects of the drug are reversible in vivo, but not in vitro. In studies, the chemical has been shown to not interact in vivo with other neurotransmitter or drug receptor sites.

See also

References

  1. Kan, JP; Steinberg, R; Leclercq, J; Worms, P; Biziere, K (1988). "Monoamine oxidase-inhibiting properties of SR 95191, a new pyridazine derivative, in the rat: Evidence for selective and reversible inhibition of monoamine oxidase type a in vivo but not in vitro". Journal of neurochemistry. 50 (4): 1137–44. PMID 3346672.
  2. Kan, JP; Steinberg, R; Mouget-Goniot, C; Worms, P; Bizière, K (1987). "SR 95191, a selective inhibitor of type a monoamine oxidase with dopaminergic properties. II. Biochemical characterization of monoamine oxidase inhibition". The Journal of Pharmacology and Experimental Therapeutics. 240 (1): 251–8. PMID 3100771.


Antidepressants (N06A)
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SSRIsTooltip Selective serotonin reuptake inhibitors
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