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The aminopenicillins are a group of antibiotics in the penicillin family that are structural analogs of ampicillin (which is the 2-amino derivative of benzylpenicillin, hence the name). Like other penicillins and beta-lactam antibiotics, they contain a beta-lactam ring that is crucial to its antibacterial activity.

Aminopenicillins feature a positively charged amino group that enhances their uptake through bacterial porin channels. This does not, however, prevent resistance conferred by bacterial beta-lactamases. Members of this family include ampicillin, amoxicillin and bacampicillin.

See also

• Penicillin
• Extended-spectrum penicillin
• Carboxypenicillin
• β-Lactamase inhibitor

References

1. Cunha BA (August 1992). "Aminopenicillins in urology". Urology. 40 (2): 186–90. doi:10.1016/0090-4295(92)90525-2. PMID 1502761.
2. Golan, David E. (2011-12-15). Principles of Pharmacology. Philadelphia, PA: Lippincott Williams & Wilkins. ISBN 9781608312702.
3. "Mayo Clinic Proceedings". Archived from the original on 2020-05-26. Retrieved 2008-12-26.

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