Clometocillin - Misplaced Pages

Chemical compound Pharmaceutical compound

Clometocillin
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	J01CE07 (WHO)
Identifiers
IUPAC name (2S,5R,6R)-6-(amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicycloheptane-2-carboxylic acid
CAS Number	1926-49-4
PubChem CID	71807
ChemSpider	64831
UNII	YI8LL014GF
KEGG	D07236
ChEBI	CHEBI:131732
ChEMBL	ChEMBL2106548
CompTox Dashboard (EPA)	DTXSID20172859
ECHA InfoCard	100.016.053
Chemical and physical data
Formula	C₁₇H₁₈Cl₂N₂O₅S
Molar mass	433.30 g·mol
3D model (JSmol)	Interactive image
SMILES O=C(O)2N3C(=O)(NC(=O)C(OC)c1ccc(Cl)c(Cl)c1)3SC2(C)C

Clometocillin (or clometacillin) is a penicillin.

References

Vanhoof R (September 1998). "Comparative in-vitro activities of amoxycillin and penicillin against Streptococcus pneumoniae isolates". The Journal of Antimicrobial Chemotherapy. 42 (3): 397–8. doi:10.1093/jac/42.3.397. PMID 9786482.
"Clometocillin". Pharmaceutical Manufacturing Encyclopedia (3rd ed.). Norwich, N.Y.: William Andrew Publishing. 2007. p. 1091. ISBN 978-0-8155-1856-3.

β-lactams
(inhibit synthesis
of peptidoglycan
layer of bacterial
cell wall by binding
to and inhibiting
PBPs, a group of
D-alanyl-D-alanine
transpeptidases)

β-lactamase sensitive (1st generation)	Benzylpenicillin (G) Benzathine benzylpenicillin Procaine benzylpenicillin Phenoxymethylpenicillin (V) Propicillin Pheneticillin Azidocillin Clometocillin Penamecillin
β-lactamase resistant (2nd generation)	Cloxacillin (Dicloxacillin Flucloxacillin) Oxacillin Nafcillin Methicillin

Aminopenicillins (3rd generation)	Amoxicillin Ampicillin (Pivampicillin Hetacillin Bacampicillin Lenampicillin Metampicillin Talampicillin) Epicillin
Carboxypenicillins (4th generation)	Ticarcillin Carbenicillin / Carindacillin Temocillin
Ureidopenicillins (4th generation)	Piperacillin Azlocillin Mezlocillin
Other	Mecillinam (Pivmecillinam) Sulbenicillin

1st generation	Cefazolin Cefalexin Cefadroxil Cefapirin Cefazedone Cefazaflur Cefradine Cefroxadine Ceftezole Cefaloglycin Cefacetrile Cefalonium Cefaloridine Cefalotin Cefatrizine
2nd generation	Cefaclor Cefprozil Cefuroxime Cefuroxime axetil Cefamandole Cefonicid Ceforanide Cefuzonam Cephamycin (Cefoxitin Cefotetan Cefminox Cefbuperazone Cefmetazole) Carbacephem (Loracarbef)
3rd generation	Cefixime Ceftriaxone Cefotaxime Antipseudomonal (Ceftazidime Cefoperazone) Cefdinir Cefcapene Cefdaloxime Ceftizoxime Cefmenoxime Cefpiramide Cefpodoxime Ceftibuten Cefditoren Cefotiam Cefetamet Cefodizime Cefpimizole Cefsulodin Cefteram Ceftiolene Oxacephem (Flomoxef Latamoxef)
4th generation	Cefepime Cefozopran Cefpirome Cefquinome
5th generation	Ceftaroline fosamil Ceftolozane Ceftobiprole
Siderophore	Cefiderocol
Veterinary	Ceftiofur Cefquinome Cefovecin

Combinations

Lipopeptides	Insert into bacterial cell wall causing perforation and depolarization: Daptomycin Surfactin
Other	Inhibits PG elongation and crosslinking: Ramoplanin

Intracellular

Inhibit PG subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
DADAL/AR inhibitors (Cycloserine)
bactoprenol inhibitors (Bacitracin)

Other

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