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Elvucitabine

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Medication
This article needs to be updated. Please help update this article to reflect recent events or newly available information. (January 2014)
Pharmaceutical compound
Elvucitabine
Clinical data
ATC code
  • none
Identifiers
IUPAC name
  • 4-amino-5-fluoro-1-pyrimidin-2-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
NIAID ChemDB
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC9H10FN3O3
Molar mass227.195 g·mol
3D model (JSmol)
SMILES
  • c1c(c(nc(=O)n12C=C(O2)CO)N)F
InChI
  • InChI=1S/C9H10FN3O3/c10-6-3-13(9(15)12-8(6)11)7-2-1-5(4-14)16-7/h1-3,5,7,14H,4H2,(H2,11,12,15)/t5-,7+/m1/s1
  • Key:HSBKFSPNDWWPSL-VDTYLAMSSA-N
  (what is this?)  (verify)

Elvucitabine is an experimental nucleoside reverse transcriptase inhibitor (NRTI), developed by Achillion Pharmaceuticals, Inc. for the treatment of HIV infection.

Elvucitabine belongs to a class of HIV drugs called nucleoside reverse transcriptase inhibitors (NRTIs). By blocking reverse transcriptase enzymes, NRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

Elvucitabine is similar in chemical structure to the FDA-approved NRTIs lamivudine (brand name Epivir) and emtricitabine (brand name Emtriva). However, in vitro studies have suggested that elvucitabine may affect certain HIV strains resistant to other NRTIs, such as lamivudine and emtricitabine.

Studies have also suggested that elvucitabine may be effective against hepatitis B virus (HBV). Mechanism of action of Elvucitabine ; reveals that it acts by inhibiting reverse transcriptase which interferes with generation of DNA copies of viral RNA.

Currently, it is in Phase II clinical trials.

References

  1. Ghosh RK, Ghosh SM, Chawla S (January 2011). "Recent advances in antiretroviral drugs". Expert Opinion on Pharmacotherapy. 12 (1): 31–46. doi:10.1517/14656566.2010.509345. PMID 20698725. S2CID 20414056.
  2. "HIV Drugs in Development". National Institute of Allergy and Infectious Diseases (NIAID). United States National Institutes of Health. Archived from the original on 2014-11-29. Retrieved 2014-11-22.
  3. Block TM, Rawat S, Brosgart CL (September 2015). "Chronic hepatitis B: A wave of new therapies on the horizon". Antiviral Research. 121: 69–81. doi:10.1016/j.antiviral.2015.06.014. PMC 5391532. PMID 26112647.
  4. "Elvucitabine".
  5. "Elvucitabine". AIDSmeds.com. November 5, 2007. Archived from the original on March 21, 2008. Retrieved March 21, 2008.
Antiviral drugs: antiretroviral drugs used against HIV (primarily J05)
Capsid inhibitors
Entry/fusion inhibitors
(Discovery and development)
Integrase inhibitors
(Integrase strand transfer inhibitors (INSTI))
Maturation inhibitors
Protease Inhibitors (PI)
(Discovery and development)
1 generation
2 generation
Reverse-transcriptase
inhibitors (RTIs)
Nucleoside and
nucleotide (NRTI)
Non-nucleoside (NNRTI)
(Discovery and development)
1 generation
2 generation
Combined formulations
Pharmacokinetic boosters
Experimental agents
Uncoating inhibitors
Transcription inhibitors
Translation inhibitors
BNAbs
Other
Failed agents
°DHHS recommended initial regimen options. Formerly or rarely used agent.
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