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GFRA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GH0
Identifiers
Aliases	GFRA3, GDNFR3, GDNF family receptor alpha 3
External IDs	OMIM: 605710; MGI: 1201403; HomoloGene: 1146; GeneCards: GFRA3; OMA:GFRA3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.2 Start 138,252,380 bp End 138,274,621 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 B1 Start 34,822,951 bp End 34,853,440 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spinal ganglia trigeminal ganglion tibial nerve testicle sural nerve gonad muscle layer of sigmoid colon vena cava seminal vesicula mucosa of transverse colon Top expressed in lumbar spinal ganglion trigeminal ganglion superior cervical ganglion external carotid artery embryo urethra female urethra male urethra internal carotid artery carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding axon guidance receptor activity protein binding signaling receptor activity Cellular component membrane anchored component of membrane external side of plasma membrane extrinsic component of membrane plasma membrane cytosol receptor complex Biological process neuron development neuron migration peripheral nervous system development sympathetic nervous system development signal transduction nervous system development MAPK cascade axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2676 14587 Ensembl ENSG00000146013 ENSMUSG00000024366 UniProt O60609 O35118 RefSeq (mRNA) NM_001496 NM_010280 RefSeq (protein) NP_001487 NP_034410 Location (UCSC) Chr 5: 138.25 – 138.27 Mb Chr 18: 34.82 – 34.85 Mb PubMed search
Wikidata
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GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a protein that in humans is encoded by the GFRA3 gene.

Function

The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the artemin ligand.

In mouse models of osteoarthritis, GFRα3 was upregulated in sensory nerves. Treating arthritic mice with monoclonal antibodies that bind to GFRα3 prevents artemin from binding there and signaling pain. Treated mice were able to use their limbs again two hours post-treatment.

See also

• GFRα

References

1. ^ GRCh38: Ensembl release 89: ENSG00000146013 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000024366 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM (Dec 1997). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". The Journal of Biological Chemistry. 272 (52): 33111–7. doi:10.1074/jbc.272.52.33111. PMID 9407096.
6. ^ "Entrez Gene: GFRA3 GDNF family receptor alpha 3".
7. Irving, Michael (2022-01-31). ""Pain pathway" a promising new drug target to treat osteoarthritis pain". New Atlas. Retrieved 2022-02-01.

Further reading

• Wang X, Baloh RH, Milbrandt J, Garcia KC (Jun 2006). "Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors". Structure. 14 (6): 1083–92. doi:10.1016/j.str.2006.05.010. PMID 16765900.
• Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gimm O, Dziema H, Brown J, Hoang-Vu C, Hinze R, Dralle H, Mulligan LM, Eng C (Apr 2001). "Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma". Oncogene. 20 (17): 2161–70. doi:10.1038/sj.onc.1204289. PMID 11360200.
• Onochie CI, Korngut LM, Vanhorne JB, Myers SM, Michaud D, Mulligan LM (Sep 2000). "Characterisation of the human GFRalpha-3 locus and investigation of the gene in Hirschsprung disease". Journal of Medical Genetics. 37 (9): 674–9. doi:10.1136/jmg.37.9.674. PMC 1734691. PMID 10978357.
• Baloh RH, Tansey MG, Lampe PA, Fahrner TJ, Enomoto H, Simburger KS, Leitner ML, Araki T, Johnson EM, Milbrandt J (December 1998). "Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex". Neuron. 21 (6): 1291–302. doi:10.1016/S0896-6273(00)80649-2. PMID 9883723. S2CID 18633359.
• Baloh RH, Gorodinsky A, Golden JP, Tansey MG, Keck CL, Popescu NC, Johnson EM, Milbrandt J (May 1998). "GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family". Proceedings of the National Academy of Sciences of the United States of America. 95 (10): 5801–6. Bibcode:1998PNAS...95.5801B. doi:10.1073/pnas.95.10.5801. PMC 20460. PMID 9576965.
• Masure S, Cik M, Pangalos MN, Bonaventure P, Verhasselt P, Lesage AS, Leysen JE, Gordon RD (Feb 1998). "Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3)". European Journal of Biochemistry. 251 (3): 622–30. doi:10.1046/j.1432-1327.1998.2510622.x. PMID 9490034.
• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (September 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.

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