| fibroblast growth factor 22 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FGF22 | ||||||
| NCBI gene | 27006 | ||||||
| HGNC | 3679 | ||||||
| OMIM | 605831 | ||||||
| RefSeq | NM_020637 | ||||||
| UniProt | Q9HCT0 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.3 | ||||||
| |||||||
Fibroblast growth factor 22 is a protein which in humans is encoded by the FGF22 gene.
Function
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development.
References
- Umemori H, Linhoff MW, Ornitz DM, Sanes JR (July 2004). "FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain". Cell. 118 (2): 257–70. doi:10.1016/j.cell.2004.06.025. PMID 15260994. S2CID 18836066.
- Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM (June 2006). "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family". The Journal of Biological Chemistry. 281 (23): 15694–700. doi:10.1074/jbc.M601252200. PMC 2080618. PMID 16597617.
- "Entrez Gene: Fibroblast growth factor 22".
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
| Growth factors | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Fibroblast |
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| EGF-like domain | |||||||||
| TGFβ pathway | |||||||||
| Insulin/IGF/ Relaxin family |
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| Platelet-derived | |||||||||
| Vascular endothelial | |||||||||
| Other | |||||||||
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