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FGF12

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Protein-coding gene in the species Homo sapiens

FGF12
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1Q1U, 4JQ0

Identifiers
AliasesFGF12, FGF12B, FHF1, fibroblast growth factor 12, EIEE47, DEE47
External IDsOMIM: 601513; MGI: 109183; HomoloGene: 10874; GeneCards: FGF12; OMA:FGF12 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)
Chromosome 3 (human)Genomic location for FGF12Genomic location for FGF12
Band3q28-q29Start192,139,390 bp
End192,767,764 bp
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)
Chromosome 16 (mouse)Genomic location for FGF12Genomic location for FGF12
Band16 B2|16 19.38 cMStart27,978,850 bp
End28,571,820 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right auricle

  • cardiac muscle tissue of right atrium

  • apex of heart

  • Pons

  • myocardium of left ventricle

  • right ventricle

  • right adrenal cortex

  • left adrenal cortex

  • middle temporal gyrus

  • prefrontal cortex
Top expressed in
  • superior frontal gyrus

  • medial dorsal nucleus

  • facial motor nucleus

  • dentate gyrus of hippocampal formation granule cell

  • medial geniculate nucleus

  • pontine nuclei

  • anterior horn of spinal cord

  • lateral septal nucleus

  • lateral geniculate nucleus

  • medial vestibular nucleus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2257

14167

Ensembl

ENSG00000114279

ENSMUSG00000022523

UniProt

P61328

P61329

RefSeq (mRNA)

NM_004113
NM_021032
NM_001377292
NM_001377293
NM_001377294

NM_001276419
NM_001276420
NM_010199
NM_183064
NM_001357064

RefSeq (protein)

NP_004104
NP_066360
NP_001364221
NP_001364222
NP_001364223

NP_001263348
NP_001263349
NP_034329
NP_898887
NP_001343993

Location (UCSC)Chr 3: 192.14 – 192.77 MbChr 16: 27.98 – 28.57 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000114279Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022523Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Oct 1996). "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". Proc Natl Acad Sci U S A. 93 (18): 9850–7. Bibcode:1996PNAS...93.9850S. doi:10.1073/pnas.93.18.9850. PMC 38518. PMID 8790420.
  6. Liu Y, Chiu IM (Nov 1997). "Assignment of FGF12, the human FGF homologous factor 1 gene, to chromosome 3q29-->3qter by fluorescence in situ hybridization". Cytogenet Cell Genet. 78 (1): 48–9. doi:10.1159/000134625. PMID 9345906.
  7. ^ "Entrez Gene: FGF12 fibroblast growth factor 12".

Further reading

PDB gallery
  • 1q1u: Crystal structure of human FHF1b (FGF12b) 1q1u: Crystal structure of human FHF1b (FGF12b)
Growth factors
Fibroblast
FGF receptor ligands:
KGF
FGF homologous factors:
hormone-like: FGF15/19
EGF-like domain
TGFβ pathway
Insulin/IGF/
Relaxin family
Insulin and Insulin-like growth factor
Relaxin family peptide hormones
Platelet-derived
Vascular endothelial
Other
Growth factor receptor modulators
Angiopoietin
CNTF
EGF (ErbB)
EGF
(ErbB1/HER1)
ErbB2/HER2
  • Agonists: Unknown/none
ErbB3/HER3
ErbB4/HER4
FGF
FGFR1
FGFR2
FGFR3
FGFR4
Unsorted
HGF (c-Met)
IGF
IGF-1
IGF-2
Others
LNGF (p75)
PDGF
RET (GFL)
GFRα1
GFRα2
GFRα3
GFRα4
Unsorted
SCF (c-Kit)
TGFβ
Trk
TrkA
  • Negative allosteric modulators: VM-902A
TrkB
TrkC
VEGF
Others
  • Additional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)


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