GFRA4 - Misplaced Pages

(Redirected from GFRα4) Protein-coding gene in the species Homo sapiens

GFRA4

Identifiers

GFRA4, GDNF family receptor alpha 4

External IDs

MGI: 1341873; HomoloGene: 10565; GeneCards: GFRA4; OMA:GFRA4 - orthologs

Gene location (Human)

Chr.	Chromosome 20 (human)

Band	20p13	Start	3,659,248 bp
Band	20p13	End	3,663,399 bp

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)

Band	2 F1\|2 63.26 cM	Start	130,881,552 bp
Band	2 F1\|2 63.26 cM	End	130,885,008 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

gonad

periodontal fiber

right lobe of thyroid gland

prefrontal cortex

left lobe of thyroid gland

Amygdala

hippocampus proper

Brodmann area 9

kidney

Top expressed in

urinary bladder

striatum of neuraxis

superior frontal gyrus

primary visual cortex

hippocampus proper

dentate gyrus of hippocampal formation granule cell

olfactory bulb

substantia nigra

spermatocyte

thyroid gland

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	glial cell-derived neurotrophic factor receptor activity signaling receptor activity
Cellular component	extracellular region membrane anchored component of membrane plasma membrane intracellular anatomical structure extracellular space external side of plasma membrane receptor complex
Biological process	negative regulation of ossification glial cell-derived neurotrophic factor receptor signaling pathway MAPK cascade axon guidance nervous system development
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


64096


14588

Ensembl


ENSG00000125861


ENSMUSG00000027316

UniProt


Q9GZZ7


Q9JJT2

RefSeq (mRNA)


NM_022139 NM_145762 NM_145763


NM_001136063 NM_001271001 NM_001271002 NM_020014

RefSeq (protein)


NP_071422 NP_665705

NP_001129535 NP_001257930 NP_001257931 NP_064398 NP_001394167
NP_001394168

Location (UCSC)

Chr 20: 3.66 – 3.66 Mb

Chr 2: 130.88 – 130.89 Mb

PubMed search

Wikidata

View/Edit Human

View/Edit Mouse

GDNF family receptor alpha-4 (GFRα4), also known as the persephin receptor, is a protein that in humans is encoded by the GFRA4 gene.

References

^ GRCh38: Ensembl release 89: ENSG00000125861 – Ensembl, May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000027316 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: GFRA4 GDNF family receptor alpha 4".

Growth factor receptor modulators

Angiopoietin

Agonists: Angiopoietin 1
Angiopoietin 4

Antagonists: Angiopoietin 2
Angiopoietin 3

Kinase inhibitors: Altiratinib
CE-245677
Rebastinib

Antibodies: Evinacumab (against angiopoietin 3)
Nesvacumab (against angiopoietin 2)

CNTF

Agonists: Axokine
CNTF
Dapiclermin

EGF (ErbB)

EGF (ErbB1/HER1)	Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen Epiregulin Heparin-binding EGF-like growth factor (HB-EGF) Murodermin Nepidermin Transforming growth factor alpha (TGFα) Kinase inhibitors: Afatinib Agerafenib Brigatinib Canertinib Dacomitinib Erlotinib Gefitinib Grandinin Icotinib Lapatinib Neratinib Osimertinib Vandetanib WHI-P 154 Antibodies: Cetuximab Depatuxizumab Depatuxizumab mafodotin Futuximab Imgatuzumab Matuzumab Necitumumab Nimotuzumab Panitumumab Zalutumumab
ErbB2/HER2	Agonists: Unknown/none Antibodies: Ertumaxomab Pertuzumab Trastuzumab Trastuzumab deruxtecan Trastuzumab duocarmazine Trastuzumab emtansine Kinase inhibitors: Afatinib Lapatinib Mubritinib Neratinib Tucatinib
ErbB3/HER3	Agonists: Neuregulins (heregulins) (1, 2, 6 (neuroglycan C)) Antibodies: Duligotumab Patritumab Seribantumab
ErbB4/HER4	Agonists: Betacellulin Epigen Heparin-binding EGF-like growth factor (HB-EGF) Neuregulins (heregulins) (1, 2, 3, 4, 5 (tomoregulin, TMEFF))

FGF

FGFR1	Agonists: Ersofermin FGF (1, 2 (bFGF), 3, 4, 5, 6, 8, 10 (KGF2), 20) Repifermin Selpercatinib Trafermin Velafermin
FGFR2	Agonists: Ersofermin FGF (1, 2 (bFGF), 3, 4, 5, 6, 7 (KGF), 8, 9, 10 (KGF2), 17, 18, 22) Palifermin Repifermin Selpercatinib Sprifermin Trafermin Antibodies: Aprutumab Aprutumab ixadotin Kinase inhibitors: Infigratinib
FGFR3	Agonists: Ersofermin FGF (1, 2 (bFGF), 4, 8, 9, 18, 23) Selpercatinib Sprifermin Trafermin Antibodies: Burosumab (against FGF23)
FGFR4	Agonists: Ersofermin FGF (1, 2 (bFGF), 4, 6, 8, 9, 19) Trafermin
Unsorted	Agonists: FGF15/19

HGF (c-Met)

Agonists: Fosgonimeton
Hepatocyte growth factor

Potentiators: Dihexa (PNB-0408)

IGF

IGF-1

IGF-2

Agonists: Insulin-like growth factor-2 (somatomedin A)

Antibodies: Dusigitumab
Xentuzumab (against IGF-1 and IGF-2)

Others

Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7)

Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1)
Trofinetide

LNGF (p75)

Antibodies: Against NGF: ABT-110 (PG110)
ASP-6294
Fasinumab
Frunevetmab
Fulranumab
MEDI-578
Ranevetmab
Tanezumab

Aptamers: Against NGF: RBM-004

Decoy receptors: LEVI-04 (p75-Fc)

PDGF

Agonists: Becaplermin
Platelet-derived growth factor (A, B, C, D)

RET (GFL)

GFRα1	Agonists: Glial cell line-derived neurotrophic factor (GDNF) Liatermin Kinase inhibitors: Vandetanib
GFRα2	Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib
GFRα3	Agonists: Artemin (ARTN) Kinase inhibitors: Vandetanib
GFRα4	Agonists: Persephin (PSPN) Kinase inhibitors: Vandetanib
Unsorted	Kinase inhibitors: Agerafenib