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Murodermin

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Chemical compound Pharmaceutical compound
Murodermin
Clinical data
Other namesRecombinant murine epidermal growth factor; rmEGF
Identifiers
IUPAC name
  • H-Asn-Ser-Tyr-Pro-Gly-Cys(1)-Pro-Ser-Ser-Tyr-Asp-Gly-Tyr-Cys(2)-Leu-Asn-Gly-Gly-Val-Cys(1)-Met-His-Ile-Glu-Ser-Leu-Asp-Ser-Tyr-Thr-Cys(2)-Asn-Cys(3)-Val-Ile-Gly-Tyr-Ser-Gly-Asp-Arg-Cys(3)-Gln-Thr-Arg-Asp-Leu-Arg-Trp-Trp-Glu-Leu-Arg-OH
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC257H375N73O83S7
Molar mass6039.68 g·mol
3D model (JSmol)
SMILES
  • CC(C)1C(=O)N(C(=O)N(C(=O)N(C(=O)N(C(=O)N(C(=O)N(C(=O)N(C(=O)N(CSSC2C(=O)N(C(=O)N(C(=O)NCC(=O)NCC(=O)N(C(=O)N(CSSC(C(=O)N3CCC3C(=O)N(C(=O)N(C(=O)N(C(=O)N(C(=O)NCC(=O)N(C(=O)N2)CC4=CC=C(C=C4)O)CC(=O)O)CC5=CC=C(C=C5)O)CO)CO)NC(=O)CNC(=O)6CCCN6C(=O)(CC7=CC=C(C=C7)O)NC(=O)(CO)NC(=O)(CC(=O)N)N)C(=O)N(C(=O)N(C(=O)N1)CC8=CN=CN8)CCSC)C(C)C)CC(=O)N)CC(C)C)C(=O)N(CC(=O)N)C(=O)N9CSSC(NC(=O)(NC(=O)(NC(=O)CNC(=O)(NC(=O)(NC(=O)CNC(=O)(NC(=O)(NC9=O)C(C)C)(C)CC)CC1=CC=C(C=C1)O)CO)CC(=O)O)CCCNC(=N)N)C(=O)N(CCC(=O)N)C(=O)N((C)O)C(=O)N(CCCNC(=N)N)C(=O)N(CC(=O)O)C(=O)N(CC(C)C)C(=O)N(CCCNC(=N)N)C(=O)N(CC1=CNC2=CC=CC=C21)C(=O)N(CC1=CNC2=CC=CC=C21)C(=O)N(CCC(=O)O)C(=O)N(CC(C)C)C(=O)N(CCCNC(=N)N)C(=O)O)(C)O)CC1=CC=C(C=C1)O)CO)CC(=O)O)CC(C)C)CO)CCC(=O)O
InChI
  • InChI=1S/C257H375N73O83S7/c1-20-123(15)203-245(404)283-103-192(351)285-157(80-127-42-52-135(339)53-43-127)222(381)313-171(104-331)210(369)281-101-191(350)287-167(92-198(360)361)228(387)290-146(37-27-70-273-255(265)266)213(372)318-177(238(397)292-148(62-65-185(259)344)217(376)327-205(125(17)337)249(408)294-147(38-28-71-274-256(267)268)212(371)309-168(93-199(362)363)229(388)298-153(76-117(3)4)218(377)289-145(36-26-69-272-254(263)264)211(370)303-162(86-133-96-277-144-35-25-23-33-141(133)144)226(385)304-161(85-132-95-276-143-34-24-22-32-140(132)143)225(384)291-149(63-66-195(354)355)214(373)297-154(77-118(5)6)219(378)296-152(253(412)413)39-29-72-275-257(269)270)110-415-418-114-181(242(401)324-202(122(13)14)247(406)326-203)320-227(386)165(90-188(262)347)307-241(400)180-113-417-416-111-178-240(399)300-156(79-120(9)10)220(379)306-164(89-187(261)346)208(367)279-98-189(348)278-99-194(353)323-201(121(11)12)246(405)321-179(239(398)293-151(68-75-414-19)216(375)305-163(87-134-97-271-116-284-134)232(391)325-204(124(16)21-2)248(407)295-150(64-67-196(356)357)215(374)314-173(106-333)233(392)299-155(78-119(7)8)221(380)310-169(94-200(364)365)230(389)315-174(107-334)234(393)302-160(83-130-48-58-138(342)59-49-130)231(390)328-206(126(18)338)250(409)322-180)112-419-420-115-182(288-193(352)102-282-243(402)183-40-30-73-329(183)251(410)170(84-131-50-60-139(343)61-51-131)311-236(395)172(105-332)312-207(366)142(258)88-186(260)345)252(411)330-74-31-41-184(330)244(403)317-176(109-336)237(396)316-175(108-335)235(394)301-159(82-129-46-56-137(341)57-47-129)224(383)308-166(91-197(358)359)209(368)280-100-190(349)286-158(223(382)319-178)81-128-44-54-136(340)55-45-128/h22-25,32-35,42-61,95-97,116-126,142,145-184,201-206,276-277,331-343H,20-21,26-31,36-41,62-94,98-115,258H2,1-19H3,(H2,259,344)(H2,260,345)(H2,261,346)(H2,262,347)(H,271,284)(H,278,348)(H,279,367)(H,280,368)(H,281,369)(H,282,402)(H,283,404)(H,285,351)(H,286,349)(H,287,350)(H,288,352)(H,289,377)(H,290,387)(H,291,384)(H,292,397)(H,293,398)(H,294,408)(H,295,407)(H,296,378)(H,297,373)(H,298,388)(H,299,392)(H,300,399)(H,301,394)(H,302,393)(H,303,370)(H,304,385)(H,305,375)(H,306,379)(H,307,400)(H,308,383)(H,309,371)(H,310,380)(H,311,395)(H,312,366)(H,313,381)(H,314,374)(H,315,389)(H,316,396)(H,317,403)(H,318,372)(H,319,382)(H,320,386)(H,321,405)(H,322,409)(H,323,353)(H,324,401)(H,325,391)(H,326,406)(H,327,376)(H,328,390)(H,354,355)(H,356,357)(H,358,359)(H,360,361)(H,362,363)(H,364,365)(H,412,413)(H4,263,264,272)(H4,265,266,273)(H4,267,268,274)(H4,269,270,275)/t123-,124-,125+,126+,142-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,201-,202-,203-,204-,205-,206-/m0/s1
  • Key:WLGOTMXHWBRTJA-GACYYNSASA-N

Murodermin (INN), also known as recombinant murine epidermal growth factor (rmEGF), is a recombinant form of mouse epidermal growth factor (EGF) and an EGF receptor agonist which was never marketed.

See also

References

  1. Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 112–. ISBN 978-94-011-4439-1.
  2. Thurlow KJ (6 December 2012). Chemical Nomenclature. Springer Science & Business Media. pp. 222–. ISBN 978-94-011-4958-7.


Growth factor receptor modulators
Angiopoietin
CNTF
EGF (ErbB)
EGF
(ErbB1/HER1)
ErbB2/HER2
  • Agonists: Unknown/none
ErbB3/HER3
ErbB4/HER4
FGF
FGFR1
FGFR2
FGFR3
FGFR4
Unsorted
HGF (c-Met)
IGF
IGF-1
IGF-2
Others
LNGF (p75)
PDGF
RET (GFL)
GFRα1
GFRα2
GFRα3
GFRα4
Unsorted
SCF (c-Kit)
TGFβ
Trk
TrkA
  • Negative allosteric modulators: VM-902A
TrkB
TrkC
VEGF
Others
  • Additional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)


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