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<!--Pharmacokinetic data--> | <!--Pharmacokinetic data--> | ||
| bioavailability = ? | | bioavailability = ? | ||
| metabolism = |
| metabolism = metabolized in the liver to active metabolites | ||
| elimination_half-life = 7 hours | | elimination_half-life = 7 hours | ||
| excretion = ] (85%) and fecal (7%) | | excretion = ] (85%) and fecal (7%) |
Revision as of 08:51, 13 April 2012
Pharmaceutical compoundClinical data | |
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AHFS/Drugs.com | Monograph |
MedlinePlus | a682482 |
License data |
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Pregnancy category |
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Routes of administration | Oral |
ATC code | |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | ? |
Metabolism | metabolized in the liver to active metabolites |
Elimination half-life | 7 hours |
Excretion | Renal (85%) and fecal (7%) |
Identifiers | |
IUPAC name
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CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.013.262 |
Chemical and physical data | |
Formula | C14H21N3O3S |
Molar mass | 311.401 g/mol g·mol |
3D model (JSmol) | |
SMILES
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InChI
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(verify) |
Tolazamide is an oral blood glucose lowering drug used for people with Type 2 diabetes. It is part of the sulfonylurea family (ATC A10BB).
Synthesis
para-Toluenesulfonamide is converted to its carbamate with ethyl chloroformate in the presence of a base. Heating that intermediate with azepane leads to the displacement of the ethoxy group and the formation of tolazemide:
References
- Wright, J. B.; Willette, R. E. (1962). J. Med. Chem. 5 (4): 815–822. doi:10.1021/jm01239a016.
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(help)CS1 maint: multiple names: authors list (link)
External links
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