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Isopropamide

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(Redirected from Isopropamide iodide) Chemical compound Pharmaceutical compound
Isopropamide
Clinical data
MedlinePlusa694006
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • US: ℞-only and Unscheduled
  • In general: unscheduled
Identifiers
IUPAC name
  • 4-amino-N,N-diisopropyl-N-methyl-4-oxo-3,3-diphenylbutan-1-aminium
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.028.470 Edit this at Wikidata
Chemical and physical data
FormulaC23H33N2O
Molar mass353.530 g·mol
3D model (JSmol)
SMILES
  • O=C(N)C(c1ccccc1)(c2ccccc2)CC(C(C)C)(C(C)C)C
InChI
  • InChI=1S/C23H32N2O/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26)/p+1
  • Key:JTPUMZTWMWIVPA-UHFFFAOYSA-O
  (what is this?)  (verify)

Isopropamide (R79) is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity (gastrointestinal acidosis) and hypermotility. Chemically, it contains a quaternary ammonium group. It is most often provided as an iodide salt, but is also available as a bromide or chloride salt. It was discovered at Janssen Pharmaceutica in 1954.

References

Further reading

  • Seeherman R (October 1957). "Isopropamide iodide: a long-acting anticholinergic". Delaware Medical Journal. 29 (10): 265–9. PMID 13473394.
  • Boss Jr EG, Buchanan GC (November 1957). "Effect of isopropamide iodide on basal gastric secretion in the human". Gastroenterology. 33 (5): 730–6. doi:10.1016/S0016-5085(19)35625-2. PMID 13480414.
Drugs for functional gastrointestinal disorders (A03)
Drugs for
functional
bowel
disorders
Antimuscarinics
Tertiary
amino group
Quaternary
ammonium
compounds
Phosphodiesterase
inhibitors
Acting on
serotonin receptors
Other
Belladonna
and derivatives
(antimuscarinics)
Propulsives
Muscarinic acetylcholine receptor modulators
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(and prodrugs)
See also
Receptor/signaling modulators
Nicotinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators
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