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PRO-LAD

Clinical data
Other names	PRO-LAD, 6-propyl- 6-nor- Lysergic acid diethylamide, (6aR,9R)- N,N- diethyl- 7-propyl- 4,6,6a,7,8,9- hexahydroindolo- quinoline- 9- carboxamide
Routes of administration	Oral
Legal status
Legal status	DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act US: Analogue to a Schedule I/II drug but only if it is intended for human consumption Illegal in France
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Renal
Identifiers
IUPAC name (8β)-N,N-Diethyl-6-propyl-9,10-didehydroergoline-8-carboxamide
CAS Number	65527-63-1
PubChem CID	44457803
ChemSpider	21106361
UNII	RVR83W9XMC
ChEMBL	ChEMBL22258
CompTox Dashboard (EPA)	DTXSID50215824
Chemical and physical data
Formula	C22H29N3O
Molar mass	351.494 g·mol
3D model (JSmol)	Interactive image
SMILES CCN(CC)C(=O)2C=C1c3cccc4cc(C1N(C2)CCC)c34
InChI InChI=1S/C22H29N3O/c1-4-10-25-14-16(22(26)24(5-2)6-3)11-18-17-8-7-9-19-21(17)15(13-23-19)12-20(18)25/h7-9,11,13,16,20,23H,4-6,10,12,14H2,1-3H3/t16-,20-/m1/s1 Key:HZKYLVLOBYNKKM-OXQOHEQNSA-N
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PRO-LAD is an analogue of LSD. It is described by Alexander Shulgin in the book TiHKAL. PRO-LAD is a psychedelic drug similar to LSD, and is around as potent as LSD itself with an active dose reported at between 100 and 200 micrograms.

Legal status

On June 10, 2014 the UK Advisory Council on the Misuse of Drugs (ACMD) recommended that PRO-LAD be specifically named in the UK Misuse of Drugs Act as a class A drug despite not identifying it as ever having been sold or any harm associated with its use. The UK Home office accepted this advice and announced a ban of the substance to be enacted on 6 January 2015 as part of The Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014.

PRO-LAD is illegal in Switzerland as of December 2015.

See also

• LSD
• AL-LAD
• ALD-52
• ETH-LAD
• FLUORETH-LAD

References

1. "Arrêté du 20 mai 2021 modifiant l'arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants" [Order of May 20, 2021 amending the order of February 22, 1990 setting the list of substances classified as narcotics]. www.legifrance.gouv.fr (in French). 20 May 2021.
2. Hoffman AJ, Nichols DE (September 1985). "Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives". Journal of Medicinal Chemistry. 28 (9): 1252–1255. doi:10.1021/jm00147a022. PMID 4032428.
3. ACMD (10 June 2014). "Update of the Generic Definition for Tryptamines" (PDF). UK Home Office. p. 12. Retrieved 10 June 2014.
4. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" [Ordinance of the EDI on the lists of narcotics, psychotropic substances, precursor substances and auxiliary chemicals]. Der Bundesrat [The Federal Council] (in German).

Further reading

• Hoffman AJ, Nichols DE (September 1985). "Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives". Journal of Medicinal Chemistry. 28 (9): 1252–1255. doi:10.1021/jm00147a022. PMID 4032428.
• Niwaguchi T, Nakahara Y, Ishii H (May 1976). "[Studies on lysergic acid diethylamide and related compounds. IV. Syntheses of various amide derivatives of norlysergic acid and related compounds]". Yakugaku Zasshi. 96 (5): 673–678. doi:10.1248/yakushi1947.96.5_673. PMID 987200.
• Pfaff RC, Huang X, Marona-Lewicka D, Oberlender R, Nichols DE (1994). "Lysergamides Revisited.". NIDA Research Monograph 146: Hallucinogens: An Update (PDF). United States Department of Health and Human Services. p. 52. Archived from the original (PDF) on 2015-07-23.

External links

• PRO-LAD entry in TIHKAL
• PRO-LAD entry in TiHKAL • info

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