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Sodium salicylate

Names
IUPAC name Sodium salicylate
Other names Salsonin, Monosodium salicylate, Sodium o-hydroxybenzoate, Sodium 2-hydroxybenzoate, Salicylic acid sodium salt, Monosodium 2-hydroxybenzoate, Diuratin, ...
Identifiers
CAS Number	54-21-7
3D model (JSmol)	Interactive image
ChemSpider	5689
DrugBank	DB01398
ECHA InfoCard	100.000.181
EC Number	200-198-0
KEGG	D00566
PubChem CID	5900
RTECS number	VO5075000
UNII	WIQ1H85SYP
CompTox Dashboard (EPA)	DTXSID5021708
InChI InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1Key: ABBQHOQBGMUPJH-UHFFFAOYSA-M InChI=1/C7H6O3.Na/c8-6-4-2-1- 3-5(6)7(9)10;/h1-4,8H,(H,9,10); /q;+1/p-1/fC7H5O3.Na/q-1;m InChI=1/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1Key: ABBQHOQBGMUPJH-REWHXWOFAO
SMILES .O=C()c1ccccc1O
Properties
Chemical formula	C7H5NaO3
Molar mass	160.11 g/mol
Appearance	White crystals
Melting point	200 °C
Solubility in water	~ 660 g/l at 20 °C
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	Harmful
NFPA 704 (fire diamond)	1 1 0
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Y verify (what is  ?) Infobox references

Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux.

Properties

Sodium salicylate is of the salicylate family and this compound is known to trigger Reye's Syndrome in children and adults, usually following a viral infection such as influenza or chicken pox. Products containing such salicylates should not be given to children under the age of 19.

Uses

It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. It is also a potential replacement for aspirin for people sensitive to it.

References

1. Lehman, J.W., Operational Organich Chemistry, 4th ed., New Jersey, Prentice Hall, 2009
2. Klampfer, Lidija (1999-04-01). "Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines". Blood. 93 (7): 2386–94. PMID 10090950. Retrieved 2011-02-21. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
3. Rae, Colin (2007-07-31). "Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis". Proceedings of the National Academy of Sciences of the USA. 104 (31): 12790–5. doi:10.1073/pnas.0701437104. PMC 1937545. PMID 17646662. Retrieved 2011-02-21. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
4. Stark, Lesley A. (2007-05). "Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer". Carcinogenesis. 28 (5): 968–76. doi:10.1093/carcin/bgl220. PMID 17132819. Retrieved 2011-02-21. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
5. Schwenger, Paul (1996-04-05). "Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate". The Journal of Biological Chemistry. 271 (14): 8089–94. doi:10.1074/jbc.271.14.8089. PMID 8626494. Retrieved 2011-02-21. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)

External links

• Chemicalland21
• Some synonyms
• Safety data for sodium salicylate at Oxford University
• Sodium salicylate, definitions at National Cancer Institute

• Sodium compounds
• Salicylates