Oxycodone/paracetamol: Difference between revisions

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			{{Short description\|Pain medication}}
	{{Globalize/USA\|date=February 2011}}
			{{Redirect2\|Percocet\|Percs\|the band\|Percocettes\|the supercomputer technology\|PERCS\|the cleaning chemical PERC\|tetrachloroethylene\|}}
			{{Use dmy dates\|date=October 2022}}
			{{cs1 config \|name-list-style=vanc \|display-authors=6}}
	{{Drugbox		{{Drugbox
			\| Verifiedfields = changed
	\| verifiedrevid = 455186406
			\| Watchedfields = changed
	\| drug_name = Percocet
			\| verifiedrevid = 455187452
			\| type = combo
			\| image =
			\| alt =
			\| caption =

	<!--Combo data-->		<!-- Combo data -->
			\| component1 = Oxycodone
	\| type = combo
			\| class1 = ]
	\| component1 = Oxycodone
			\| component2 = Acetaminophen
	\| class1 = ]
			\| class2 = ]
	\| component2 = Paracetamol
	\| class2 = ]

	<!--Clinical data-->		<!-- Clinical data -->
	\| tradename =		\| tradename = Percocet, others
	\| Drugs.com = {{drugs.com\|~~monograph~~\|oxycodone}}		\| Drugs.com = {{drugs.com\|ppa\|oxycodone-and-acetaminophen}}
			\| MedlinePlus =
	\| licence_EU = <!-- EMEA requires brand name -->
			\| DailyMedID = Oxycodone hydrochloride and acetaminophen
	\| licence_US = Percocet
	\| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->		\| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
			\| pregnancy_category =
	\| pregnancy_US = <!-- A / B / C / D / X -->
			\| routes_of_administration = ]
	\| pregnancy_category = C
			\| ATC_prefix = N02
	\| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
			\| ATC_suffix = AJ17
	\| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->

	\| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
			<!-- Legal status -->
	\| legal_US = Schedule II
			\| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled -->
	\| routes_of_administration = ]
			\| legal_AU_comment =
			\| legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F -->
			\| legal_BR_comment =
			\| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
			\| legal_CA_comment =
			\| legal_DE = <!-- Anlage I, II, III or Unscheduled -->
			\| legal_DE_comment =
			\| legal_NZ = <!-- Class A, B, C -->
			\| legal_NZ_comment =
			\| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C -->
			\| legal_UK_comment =
			\| legal_US = Schedule II
			\| legal_US_comment = <ref name="Percocet FDA label">{{cite web \| title=Percocet- oxycodone hydrochloride and acetaminophen tablet \| website=DailyMed \| url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4dd36cf5-8f73-404a-8b1d-3bd53bd90c25 \| access-date=17 October 2021}}</ref>
			\| legal_EU =
			\| legal_EU_comment =
			\| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV -->
			\| legal_UN_comment =
			\| legal_status = <!-- For countries not listed above -->

	<!--Identifiers-->		<!--Identifiers-->
			\| CAS_number_Ref = {{cascite\|correct\|??}}
	\| CAS_number = 330988-72-2
			\| CAS_number = 330988-72-2
	\| StdInChI_Ref = {{stdinchicite\|correct\|chemspider}}
			\| DrugBank =
	\| StdInChI = 1S/C18H21NO4.C8H9NO2.ClH/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10;1-6(10)9-7-2-4-8(11)5-3-7;/h3-4,13,16,21H,5-9H2,1-2H3;2-5,11H,1H3,(H,9,10);1H/t13-,16+,17+,18-;;/m1../s1
	\| ~~StdInChIKey_Ref~~ = {{~~stdinchicite~~\|correct\|chemspider}}		\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}
			\| ChemSpiderID = 4881971
	\| StdInChIKey = LPIDDOOVLLQTPE-PCHTVJFHSA-N
			\| KEGG = D02153
	\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}
	\| ChemSpiderID = 4881971

	<!--Chemical data-->
	}}		}}
	The combination ''']/]''' (North American trade name of combination '''Percocet''', North American trade name of latter '''Acetaminophen''') is a ] pain reliever used to treat moderate to severe ] (short-term) ], marketed by ].<ref>http://www.endo.com/pdf/products/Percocet_pack_insert_2.pdf</ref>

			'''Oxycodone/paracetamol''',<!-- NOTE: DO NOT CHANGE TO ACETAMINOPHEN, per ] --> sold under the brand name '''Percocet''' among others, is a ] of the opioid ] with ] (acetaminophen), used to treat moderate to severe ].<ref name="Percocet FDA label" />
	==History==
	The ] first approved Percocet (also known as "Troll JuJu" in 1976, under application ANDA 085106.<ref>{{cite web\|title=Drugs@FDA. FDA approved drug products (searchable database)\|publisher=U.S. Food and Drug Administration, Center for Drug Evaluation and Research\|url=http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm\|accessdate=2009-03-30}}</ref>

			In 2022, it was the 98th most commonly prescribed medication in the United States, with more than 6{{nbsp}}million prescriptions.<ref>{{cite web \| title=The Top 300 of 2022 \| url=https://clincalc.com/DrugStats/Top300Drugs.aspx \| website=ClinCalc \| access-date=30 August 2024 \| archive-date=30 August 2024 \| archive-url=https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx \| url-status=live }}</ref><ref>{{cite web \| title = Acetaminophen; Oxycodone Drug Usage Statistics, United States, 2013 - 2022 \| website = ClinCalc \| url = https://clincalc.com/DrugStats/Drugs/AcetaminophenOxycodone \| access-date = 30 August 2024 }}</ref>
	==Formulation==
	As of March 2006, ] produces Percocet in following dosages.<ref name=insert>{{cite web\|title=Percocet oxycodone and acetaminophen tablets USP\|publisher=Endo Pharmaceuticals\|date=2006 November\|url=http://www.endo.com/pdf/products/Percocet_pack_insert_4.pdf\|accessdate=2009-03-30}}</ref> Percocet ]s are available in six combinations of oxycodone hydrochloride and ], with different appearances and maximum daily ]s:<ref name=insert/>

			==History==
	{\| class="wikitable" style="text-align:center"
			The United States ] (FDA) first approved oxycodone/paracetamol in 1976, under application ANDA 085106.<ref>{{cite web \| title=Percocet: FDA-Approved Drugs \| website=U.S. ] (FDA) \| url=https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=085106 \| access-date=17 October 2021}}</ref>
	! Oxycodone Hydrochloride (mg) !! Acetaminophen (mg) !! Tablet Color !! Tablet Shape !! Maximum Daily Dose
	\|-
	\| 2.5 \|\| 325 \|\| pink \|\| oval \|\| 12 tablets
	\|-
	\| 5 \|\| 325 \|\| white \|\| round \|\| 12 tablets
	\|-
	\| 7.5 \|\| 325 \|\| peach \|\| oval \|\| 8 tablets
	\|-
	\| 7.5 \|\| 500 \|\| peach \|\| capsule-shaped \|\| 8 tablets
	\|-
	\| 10.0 \|\| 325 \|\| white \|\| oblong \|\| 6 tablets
	\|-
	\| 10.0 \|\| 650 \|\| yellow \|\| oval \|\| 6 tablets
	\|}

			== Society and culture ==
	For the 2.5 mg Oxycodone HCL tablet, the usual dose is 1–2 tablets every six hours as needed for pain; for the other tablets, the usual dose is 1 tablet every six hours as needed for pain.<ref name=insert/>
			=== Implicated in deaths ===
			In June 2009, an FDA advisory panel recommended that Percocet, ], and every other combination of acetaminophen with ] ]<ref>{{cite web\|url=http://www.webmd.com/pain-management/news/20090701/fda-may-restrict-acetaminophen\|title=FDA May Restrict Acetaminophen\|work=WebMD}}</ref> be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to ] and associated liver damage.<ref>{{cite news\| url=https://www.nytimes.com/2009/07/01/health/01fda.html \| work=] \| title=Ban Is Advised on 2 Top Pills for Pain Relief \| first=Gardiner \| last=Harris \| date=30 June 2009 \| access-date=22 May 2010}}</ref>

			In December 2009, a study found a fivefold increase in oxycodone-related deaths in ] (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related deaths in Ontario over the same period.<ref>{{cite journal \| vauthors = Dhalla IA, Mamdani MM, Sivilotti ML, Kopp A, Qureshi O, Juurlink DN \| title = Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone \| journal = CMAJ \| volume = 181 \| issue = 12 \| pages = 891–6 \| date = December 2009 \| pmid = 19969578 \| pmc = 2789126 \| doi = 10.1503/cmaj.090784 }}</ref><ref>{{cite journal \| vauthors = Fischer B, Rehm J \| title = Deaths related to the use of prescription opioids \| journal = CMAJ \| volume = 181 \| issue = 12 \| pages = 881–2 \| date = December 2009 \| pmid = 19969577 \| pmc = 2789122 \| doi = 10.1503/cmaj.091791 }}</ref><ref>{{cite journal\|journal=Canadian Medical Association Journal \|date=7 December 2009 \|title=Deaths from opioid use have doubled; five-fold increase in oxycodone deaths \|access-date=31 May 2012 \|url=https://www.sciencedaily.com/releases/2009/12/091207123105.htm}}</ref>
	==Use in pain management==
	This medicine, in recent years, has gained favor among the medical community due to its effectiveness and a lower addiction rate than ]. It is very useful to give to someone who is experiencing acute severe pain that is neither ] nor ].{{Citation needed\|date=February 2010}}

			== References ==
	==Implicated in deaths==
	On June 30, 2009, an FDA advisory panel recommended that Percocet, ], and every other combination of acetaminophen with ] ]<ref>http://www.webmd.com/pain-management/news/20090701/fda-may-restrict-acetaminophen</ref> be removed from the market because of their contributions to an alleged 400 acetaminophen related deaths in the United States each year, that were attributed to ] and associated liver damage.<ref>{{cite news\| url=http://www.nytimes.com/2009/07/01/health/01fda.html?em \| work=The New York Times \| title=Ban Is Advised on 2 Top Pills for Pain Relief \| first=Gardiner \| last=Harris \| date=2009-07-01 \| accessdate=2010-05-22}}</ref>

	In December 2009, the '']'' reported a study finding a fivefold increase in oxycodone-related deaths in Ontario (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related Ontario deaths over the same period.<ref></ref>

	==References==
	{{Reflist}}		{{Reflist}}

			{{Analgesics}}
	== External links==
			{{Anti-inflammatory products}}
	*
			{{Opioidergics}}

			{{Drug use}}
	{{DEFAULTSORT:Oxycodone/Paracetamol}}
			{{Portal bar \| Medicine}}
	]
			{{Authority control}}
	]


			{{DEFAULTSORT:Oxycodone Paracetamol}}
	{{analgesic-stub}}
			]
			]

Latest revision as of 02:29, 18 October 2024

Pain medication "Percocet" and "Percs" redirect here. For the band, see Percocettes. For the supercomputer technology, see PERCS. For the cleaning chemical PERC, see tetrachloroethylene.

Pharmaceutical compound

Oxycodone/paracetamol
Combination of
Oxycodone	Opioid analgesic
Acetaminophen	Anilide analgesic
Clinical data
Trade names	Percocet, others
AHFS/Drugs.com	Professional Drug Facts
License data	US DailyMed: Oxycodone hydrochloride and acetaminophen
Routes of administration	By mouth
ATC code	N02AJ17 (WHO)
Legal status
Legal status	US: Schedule II
Identifiers
CAS Number	330988-72-2
ChemSpider	4881971
KEGG	D02153
CompTox Dashboard (EPA)	DTXSID10186763
(what is this?) (verify)

Oxycodone/paracetamol, sold under the brand name Percocet among others, is a fixed-dose combination of the opioid oxycodone with paracetamol (acetaminophen), used to treat moderate to severe pain.

In 2022, it was the 98th most commonly prescribed medication in the United States, with more than 6 million prescriptions.

History

The United States Food and Drug Administration (FDA) first approved oxycodone/paracetamol in 1976, under application ANDA 085106.

Society and culture

Implicated in deaths

In June 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to acetaminophen overdose and associated liver damage.

In December 2009, a study found a fivefold increase in oxycodone-related deaths in Ontario, Canada (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related deaths in Ontario over the same period.

References

^ "Percocet- oxycodone hydrochloride and acetaminophen tablet". DailyMed. Retrieved 17 October 2021.
"The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
"Acetaminophen; Oxycodone Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.
"Percocet: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 17 October 2021.
"FDA May Restrict Acetaminophen". WebMD.
Harris G (30 June 2009). "Ban Is Advised on 2 Top Pills for Pain Relief". The New York Times. Retrieved 22 May 2010.
Dhalla IA, Mamdani MM, Sivilotti ML, Kopp A, Qureshi O, Juurlink DN (December 2009). "Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone". CMAJ. 181 (12): 891–6. doi:10.1503/cmaj.090784. PMC 2789126. PMID 19969578.
Fischer B, Rehm J (December 2009). "Deaths related to the use of prescription opioids". CMAJ. 181 (12): 881–2. doi:10.1503/cmaj.091791. PMC 2789122. PMID 19969577.
"Deaths from opioid use have doubled; five-fold increase in oxycodone deaths". Canadian Medical Association Journal. 7 December 2009. Retrieved 31 May 2012.

Analgesics (N02A, N02B)

Opioids

Opiates/opium	Codeine +aspirin +paracetamol Morphine (+naltrexone) Opium Laudanum Paregoric
Semisynthetic	Acetyldihydrocodeine Benzylmorphine Buprenorphine (+naloxone) Butorphanol Desomorphine Diamorphine (heroin) Dihydrocodeine (+paracetamol) Dihydromorphine Etorphine Ethylmorphine Hydrocodone (+paracetamol, +ibuprofen, +aspirin) Hydromorphinol Hydromorphone Levorphanol Metopon Nalbuphine Nicocodeine Nicodicodine Nicomorphine Oxycodone (+paracetamol, +aspirin, +ibuprofen, +naloxone, +naltrexone) Oxymorphone Papaveretum Thebacon
Synthetic	Alfentanil Alphaprodine Anileridine Bezitramide Carfentanil Dextromoramide Dextropropoxyphene Dezocine Dimenoxadol Dipipanone Ethoheptazine Fentanyl (+fluanisone) Ketobemidone Lofentanil Meptazinol Methadone NFEPP Norpipanone Oliceridine Pentazocine Pethidine (meperidine) Phenadoxone Phenazocine Phenoperidine Piminodine Piritramide Proheptazine Propiram Remifentanil Sufentanil Tapentadol Tilidine Tramadol (+celecoxib, +paracetamol) Viminol

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Propionates	Benoxaprofen Fenoprofen Flurbiprofen Ibuprofen (Dexibuprofen) (+paracetamol) Ketoprofen (Dexketoprofen) Loxoprofen Naproxen Oxaprozin Suprofen Tiaprofenic acid Zaltoprofen
Oxicams	Isoxicam Lornoxicam Meloxicam Piroxicam Tenoxicam
Acetates	Acemetacin Bromfenac Diclofenac Etodolac Indometacin (Indometacin farnesil) Ketorolac Sulindac Tolmetin Zomepirac
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Fenamates	Flufenamic acid Meclofenamic acid Mefenamic acid Tolfenamic acid
Salicylates	Aspirin (acetylsalicylic acid) (+paracetamol/caffeine) Aloxiprin Benorylate Carbasalate calcium Choline salicylate Diflunisal Dipyrocetyl Ethenzamide Guacetisal Imidazole salicylate Magnesium salicylate Morpholine salicylate Potassium salicylate Salicin Salicylamide Salsalate Sodium salicylate Wintergreen (methyl salicylate)
Pyrazolones	Aminophenazone Ampyrone Metamizole (dipyrone) Nifenazone Phenazone Propyphenazone (+paracetamol/caffeine)
Others	Benzydamine Floctafenine Glafenine Nabumetone Nimesulide Proquazone

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Withdrawn from market
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v t e Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
pyrazolones / pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone
salicylates	Aspirin (acetylsalicylic acid) Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bufexamac Bumadizone Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Mofezolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac
oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Pivoxicam Tenoxicam
propionic acid derivatives (profens)	Alminoprofen Benoxaprofen Carprofen Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen Ibuproxam Indoprofen Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pelubiprofen Piketoprofen Pirprofen Suprofen Tarenflurbil Tepoxalin Tiaprofenic acid Vedaprofen Zaltoprofen COX-inhibiting nitric oxide donator: Naproxcinod
n-arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Floctafenine Flufenamic acid Flunixin Flutiazin Glafenine Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid
COX-2 inhibitors (coxibs)	Apricoxib Celecoxib (+tramadol) Cimicoxib Deracoxib Etoricoxib Firocoxib Lumiracoxib Mavacoxib Parecoxib Robenacoxib Rofecoxib Valdecoxib
other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase / orgotein Tenidap
NSAID combinations	Ibuprofen/famotidine Ibuprofen/hydrocodone Ibuprofen/oxycodone Ibuprofen/paracetamol Meloxicam/bupivacaine Naproxen/diphenhydramine Naproxen/esomeprazole
Key: underline indicates initially developed first-in-class compound of specific group; WHO-Essential Medicines; withdrawn drugs; veterinary use.
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