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| {{Drugbox | {{Drugbox | ||
| | Watchedfields = changed | |||
| | verifiedrevid = |
| verifiedrevid = 424715425 | ||
| | IUPAC_name = 8-chloro-3-(methoxymethyl)-5-methyl-4H-imidazobenzodiazepin-6-one | | IUPAC_name = 8-chloro-3-(methoxymethyl)-5-methyl-4H-imidazobenzodiazepin-6-one | ||
| | image = PWZ-029_structure.png | | image = PWZ-029_structure.png | ||
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| | ATC_suffix = | | ATC_suffix = | ||
| | PubChem = 9971547 | | PubChem = 9971547 | ||
| | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | |||
| | DrugBank = | | DrugBank = | ||
Revision as of 14:17, 3 September 2011
Pharmaceutical compound | |
| Identifiers | |
|---|---|
IUPAC name
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| PubChem CID | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C14H14ClN3O2 |
| Molar mass | 291.732 g/mol g·mol |
| 3D model (JSmol) | |
SMILES
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| (verify) | |
PWZ-029 is a benzodiazepine derivative drug with nootropic effects. It acts as a subtype-selective, mixed agonist-inverse agonist at the benzodiazepine binding site on the GABAA receptor, acting as a partial inverse agonist at the α5 subtype and a weak partial agonist at the α3 subtype. This gives it a mixed pharmacological profile, producing at low doses memory-enhancing effects but with no convulsant or anxiogenic effects or muscle weakness, although at higher doses it produces some sedative effects.
See also
References
- Savić MM, Clayton T, Furtmüller R, Gavrilović I, Samardzić J, Savić S, Huck S, Sieghart W, Cook JM. PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats. Brain Research. 2008 May 7;1208:150-9. doi:10.1016/j.brainres.2008.02.020 PMID 18394590
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| N06BA Centrally acting sympathomimetics | |||||||||
| N06BC Xanthine derivatives | |||||||||
| N06BX Other psychostimulants and nootropics | |||||||||
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