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Bicyclic phosphate is a class of organophosphate compounds that are used as flame retardants, stabilizers and antioxidants. They are also used in spectroscopic studies.

Some bicyclic phosphates, such as TBPS, TBPO and IPTBO, are highly toxic. They have toxicity comparable to nerve agents. However, they are not acetylcholinesterase inhibitors. They act as GABA receptor antagonists and have potent convulsant effects.

See also

• Convulsant
• TBPS
• TBPO
• IPTBO

References

1. ^ Bellet, E. M.; Casida, J. E. (14 December 1973). "Bicyclic Phosphorus Esters: High Toxicity without Cholinesterase Inhibition". Science. 182 (4117): 1135–1136. Bibcode:1973Sci...182.1135B. doi:10.1126/science.182.4117.1135. PMID 4356280. S2CID 9462533.
2. ^ Gupta, Ramesh C., ed. (2009). Handbook of toxicology of chemical warfare agents (1st ed.). London: Academic Press. ISBN 9780123744845.
3. BOWERY, N. G.; COLLINS, J. F.; HILL, R. G. (17 June 1976). "Bicyclic phosphorus esters that are potent convulsants and GABA antagonists". Nature. 261 (5561): 601–603. Bibcode:1976Natur.261..601B. doi:10.1038/261601a0. PMID 934303. S2CID 4184150.
4. Ellison, D. Hank (2007). Handbook of chemical and biological warfare agents (2nd ed.). Boca Raton, Fla.: CRC. ISBN 9780849314346.

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