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Demecarium bromide

Clinical data
ATC code	S01EB04 (WHO)
Identifiers
IUPAC name trimethyl- decyl] carbamoyl] oxyphenyl]-ammonium dibromide
CAS Number	56-94-0
PubChem CID	5965
DrugBank	DB00944
ChemSpider	5750
UNII	61D5V4OKTP
KEGG	D00667
ChEBI	CHEBI:4391
CompTox Dashboard (EPA)	DTXSID6045240
ECHA InfoCard	100.000.274
Chemical and physical data
Formula	C32H52Br2N4O4
Molar mass	716.588 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES ..O=C(Oc1cccc(c1)(C)(C)C)N(CCCCCCCCCCN(C(=O)Oc2cccc(c2)(C)(C)C)C)C
InChI InChI=1S/C32H52N4O4.2BrH/c1-33(31(37)39-29-21-17-19-27(25-29)35(3,4)5)23-15-13-11-9-10-12-14-16-24-34(2)32(38)40-30-22-18-20-28(26-30)36(6,7)8;;/h17-22,25-26H,9-16,23-24H2,1-8H3;2*1H/q+2;;/p-2 Key:YHKBUDZECQDYBR-UHFFFAOYSA-L
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Demecarium is a parasympathomimetic that acts as an acetylcholinesterase inhibitor. It is one of several topical (applied directly to the affected area) medications used to reduce elevated intraocular pressure (IOP) associated with primary glaucoma in cats, dogs, and other animals.

See also

• Diisopropylfluorophosphate
• Intraocular pressure
• Glaucoma

References

1. Ward D, Abney K, Oliver J (2003). "The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs". Vet Ophthalmol. 6 (1): 23–5. doi:10.1046/j.1463-5224.2003.00257.x. PMID 12641839.{{cite journal}}: CS1 maint: multiple names: authors list (link)
2. Krohne S (1994). "Effect of topically applied 2% pilocarpine and 0.25% demecarium bromide on blood-aqueous barrier permeability in dogs". Am J Vet Res. 55 (12): 1729–33. PMID 7887518.
3. Gum G, Gelatt K, Gelatt J, Jones R (1993). "Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma". Am J Vet Res. 54 (2): 287–93. PMID 8430939.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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