4-Hydroxyestriol - Misplaced Pages

For other uses, see Hydroxyestriol.

4-Hydroxyestriol
Names

IUPAC name Estra-1,3,5(10)-triene-3,4,16α,17β-tetrol
Systematic IUPAC name (1R,2R,3aS,3bR,9bS,11aS)-11a-Methyl-2,3,3a,3b,4,5,9b,10,11,11a-decahydro-1H-cyclopentaphenanthrene-1,2,6,7-tetrol
Identifiers
CAS Number	60021-32-1
3D model (JSmol)	Interactive image
ChemSpider	168415
PubChem CID	194095
UNII	I8867W65UC
CompTox Dashboard (EPA)	DTXSID20975448
InChI InChI=1S/C18H24O4/c1-18-7-6-10-9-4-5-14(19)16(21)12(9)3-2-11(10)13(18)8-15(20)17(18)22/h4-5,10-11,13,15,17,19-22H,2-3,6-8H2,1H3/t10-,11-,13+,15-,17+,18+/m1/s1Key: KKXSCWWODCABHQ-OZPBLJIJSA-N
SMILES C12CC3(1C(2O)O)CCC4=C3C=CC(=C4O)O
Properties
Chemical formula	C₁₈H₂₄O₄
Molar mass	304.386 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references

Chemical compound

4-Hydroxyestriol, also known as estra-1,3,5(10)-triene-3,4,16α,17β-tetrol, is an endogenous catechol estrogen and metabolite of estriol. It has been found in pregnancy urine.

References

Theodore Fotsis Fotsis; Paula Jervenpee; Herman Adlercreutz (13 January 2009) . "Identification of 4-Hydroxyestriol in Pregnancy Urine". The Journal of Clinical Endocrinology and Metabolism. 51 (1): 148–151. doi:10.1210/jcem-51-1-148. PMID 6892918.

Others

ERTooltip Estrogen receptor

Agonists

Mixed
(SERMsTooltip Selective estrogen receptor modulators)

Antagonists

GPERTooltip G protein-coupled estrogen receptor

Agonists	2-Methoxyestradiol 7β-Hydroxyepiandrosterone Afimoxifene (4-hydroxytamoxifen) Aldosterone Atrazine Bisphenol A Daidzein DDT (p,p'-DDT, o',p'-DDE) Diarylpropionitrile Equol Estradiol Ethinylestradiol Fulvestrant (ICI-182780) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone Nicotinic acid Nicotinamide Nonylphenol Oleuropein PCBs (2,2',5'-PCB-4-OH) Propylpyrazoletriol Quercetin Raloxifene Resveratrol STX Tamoxifen Tectoridin
Antagonists	CCL18 Estriol G-15 G-36 MIBE
Unknown	Diethylstilbestrol Zearalenone

See also: Receptor/signaling modulators; Estrogens and antiestrogens; Androgen receptor modulators; Progesterone receptor modulators; List of estrogens

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