| Revision as of 12:27, 10 December 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (no changed fields - added verified revid - updated 'DrugBank_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'CAS_number_Ref') per Chem/Drugbox validation (report [[Misplaced Pages talk:WikiProject_Pharmac...← Previous edit | Revision as of 13:50, 30 October 2012 edit undo213.106.56.145 (talk) Fixed SMILED to match imageNext edit → | ||
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| | C=15 | H=21 | N=1 | | C=15 | H=21 | N=1 | ||
| | molecular_weight = 215.3339 g/mol | | molecular_weight = 215.3339 g/mol | ||
| | smiles = |
| smiles = c1(23CCCC2CCCN3)ccccc1 | ||
| | InChI = 1/C15H21N/c1-2-7-13(8-3-1)15-11-5-4-9-14(15)10-6-12-16-15/h1-3,7-8,14,16H,4-6,9-12H2 | | InChI = 1/C15H21N/c1-2-7-13(8-3-1)15-11-5-4-9-14(15)10-6-12-16-15/h1-3,7-8,14,16H,4-6,9-12H2 | ||
| | InChIKey = QEXADSRMRUUCQJ-UHFFFAOYAG | | InChIKey = QEXADSRMRUUCQJ-UHFFFAOYAG | ||
Revision as of 13:50, 30 October 2012
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| Formula | C15H21N |
| Molar mass | 215.3339 g/mol g·mol |
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8a-Phenyldecahydroquinoline (8A-PDHQ) is a high affinity NMDA antagonist. It is a structural analog of Phencyclidine with slightly lower binding affinity than the parent compound. (-)-8a-Phenyldecahydroquinoline has an in vivo potency comparable to that of (+)-MK-801.
References
- Chen C, Kozikowski AP, Wood PL, Reynolds IJ, Ball RG, Pang YP (1992). "Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency". J Med Chem. 35 (9): 1634–8. doi:10.1021/jm00087a020. PMID 1315871.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Elhallaoui M, Laguerre M, Carpy A, Ouazzani FC (2002). "Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode". J Mol Model. 8 (2): 65–72. doi:10.1007/s00894-001-0067-4. PMID 12032600.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
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