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CREBL1

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Protein-coding gene in the species Homo sapiens
ATF6B
Identifiers
AliasesATF6B, CREB-RP, CREBL1, G13, activating transcription factor 6 beta
External IDsOMIM: 600984; MGI: 105121; HomoloGene: 31238; GeneCards: ATF6B; OMA:ATF6B - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)
Chromosome 6 (human)Genomic location for ATF6BGenomic location for ATF6B
Band6p21.32Start32,115,264 bp
End32,128,253 bp
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)
Chromosome 17 (mouse)Genomic location for ATF6BGenomic location for ATF6B
Band17 B1|17 18.22 cMStart34,866,120 bp
End34,874,048 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • granulocyte

  • right uterine tube

  • left ovary

  • right ovary

  • right lobe of thyroid gland

  • spleen

  • right hemisphere of cerebellum

  • left lobe of thyroid gland

  • gallbladder
Top expressed in
  • yolk sac

  • granulocyte

  • lip

  • dentate gyrus of hippocampal formation granule cell

  • neural layer of retina

  • neural tube

  • ventricular zone

  • thymus

  • choroid plexus of fourth ventricle

  • entorhinal cortex
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1388

12915

Ensembl

ENSG00000213676
ENSG00000228628
ENSG00000234539
ENSG00000168468

ENSMUSG00000015461

UniProt

Q99941

O35451

RefSeq (mRNA)

NM_004381
NM_001136153

NM_017406

RefSeq (protein)

NP_001129625
NP_004372

n/a

Location (UCSC)Chr 6: 32.12 – 32.13 MbChr 17: 34.87 – 34.87 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

CAMP responsive element binding protein-like 1, also known as CREBL1, is a protein which in humans is encoded by the CREBL1 gene.

Function

The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.

References

  1. ^ ENSG00000228628, ENSG00000234539, ENSG00000168468 GRCh38: Ensembl release 89: ENSG00000213676, ENSG00000228628, ENSG00000234539, ENSG00000168468Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000015461Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CREBL1 cAMP responsive element binding protein-like 1".
  6. Haze K, Okada T, Yoshida H, Yanagi H, Yura T, Negishi M, Mori K (April 2001). "Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response". Biochem. J. 355 (Pt 1): 19–28. doi:10.1042/0264-6021:3550019. PMC 1221707. PMID 11256944.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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