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TEAD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5EMW
Identifiers
Aliases	TEAD3, DTEF-1, ETFR-1, TEAD-3, TEAD5, TEF-5, TEF5, TEA domain transcription factor 3
External IDs	OMIM: 603170; MGI: 109241; HomoloGene: 81821; GeneCards: TEAD3; OMA:TEAD3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.31 Start 35,473,597 bp End 35,497,079 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 A3.3|17 14.66 cM Start 28,550,645 bp End 28,569,791 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle layer of sigmoid colon gastric mucosa body of uterus left uterine tube popliteal artery tibial arteries right coronary artery thoracic aorta ascending aorta ectocervix Top expressed in lip genital tubercle esophagus trophoblast giant cell ventricular zone muscle of thigh neural layer of retina urethra female urethra molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus transcription regulator complex Biological process regulation of transcription by RNA polymerase II female pregnancy transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated hippo signaling transcription, DNA-templated asymmetric neuroblast division positive regulation of transcription by RNA polymerase II embryonic organ development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7005 21678 Ensembl ENSG00000007866 ENSMUSG00000002249 UniProt Q99594 P70210 RefSeq (mRNA) NM_003214 NM_001395214 NM_001098226 NM_001204156 NM_011566 RefSeq (protein) NP_003205 NP_001091696 NP_001191085 NP_035696 Location (UCSC) Chr 6: 35.47 – 35.5 Mb Chr 17: 28.55 – 28.57 Mb PubMed search
Wikidata
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Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3 gene.

Function

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4. Transcriptional coregulators, such as WWTR1 (TAZ) bind to these transcription factors. TEAD3 is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. It is expressed in nervous system and muscle in fish embryos. Translation of this protein is initiated at a non-AUG (AUA) start codon.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000007866 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000002249 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Jan 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics. 55 (1): 127–9. doi:10.1006/geno.1998.5628. hdl:2268/13836. PMID 9889009.
6. Jacquemin P, Martial JA, Davidson I (May 1997). "Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer". The Journal of Biological Chemistry. 272 (20): 12928–37. doi:10.1074/jbc.272.20.12928. PMID 9148898.
7. ^ "Entrez Gene: TEAD3 TEA domain family member 3".
8. Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell. 66 (1): 11–12. doi:10.1016/0092-8674(91)90132-I. PMID 2070413. S2CID 2819591.
9. Mann CJ, Osborn DP, Hughes SM (Oct 2007). "Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord". Gene Expression Patterns. 7 (8): 827–36. doi:10.1016/j.modgep.2007.08.001. PMC 3360971. PMID 17916448.

Further reading

• Jiang SW, Wu K, Eberhardt NL (Jun 1999). "Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer". Molecular Endocrinology. 13 (6): 879–89. doi:10.1210/mend.13.6.0288. PMID 10379887.
• Vaudin P, Delanoue R, Davidson I, Silber J, Zider A (Nov 1999). "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation". Development. 126 (21): 4807–16. doi:10.1242/dev.126.21.4807. PMID 10518497.
• Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML (May 2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm". Genes & Development. 15 (10): 1229–41. doi:10.1101/gad.888601. PMC 313800. PMID 11358867.
• Maeda T, Mazzulli JR, Farrance IK, Stewart AF (Jul 2002). "Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes". The Journal of Biological Chemistry. 277 (27): 24346–52. doi:10.1074/jbc.M201171200. PMID 11986313.
• Peng L, Huang Y, Jin F, Jiang SW, Payne AH (Aug 2004). "Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1". Molecular Endocrinology. 18 (8): 2049–60. doi:10.1210/me.2004-0028. PMC 3273420. PMID 15131259.

External links

• TEAD3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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