NR4A (nuclear receptor subfamily 4A) is a family of orphan nuclear receptors which act as transcription factors in neuron development and maintenance. In 2006, it was shown that members of the NR4A family were implicated in the control of skeletal muscle metabolism.
Three members have been identified in humans:
References
- Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology. 147 (11): 5217–27. doi:10.1210/en.2006-0447. PMID 16901967.
- Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (2008). "The Orphan Nuclear Receptor, NOR-1, a Target of {beta}-Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle". Endocrinology. 149 (6): 2853–65. doi:10.1210/en.2007-1202. PMID 18325999.
- Maxwell MA, Muscat GE (2006). "The NR4A subgroup: immediate early response genes with pleiotropic physiological roles". Nucl Recept Signal. 4: e002. doi:10.1621/nrs.04002. PMC 1402209. PMID 16604165.
- Maheux J, Ethier I, Rouillard C, Lévesque D (2005). "Induction patterns of transcription factors of the nur family (nurr1, nur77, and nor-1) by typical and atypical antipsychotics in the mouse brain: implication for their mechanism of action" (PDF). J. Pharmacol. Exp. Ther. 313 (1): 460–73. doi:10.1124/jpet.104.080184. hdl:20.500.11794/17025. PMID 15615863. S2CID 1436507.
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