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HMGN4
Identifiers
Aliases	HMGN4, HMG17L3, NHC, high mobility group nucleosomal binding domain 4
External IDs	HomoloGene: 105484; GeneCards: HMGN4; OMA:HMGN4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.2 Start 26,538,366 bp End 26,546,933 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte germinal epithelium Epithelium of choroid plexus epithelium of nasopharynx parietal pleura endothelial cell granulocyte superficial temporal artery endometrium smooth muscle tissue n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 10473 n/a Ensembl ENSG00000182952 n/a UniProt O00479 n/a RefSeq (mRNA) NM_006353 n/a RefSeq (protein) NP_006344 NP_006344.1 n/a Location (UCSC) Chr 6: 26.54 – 26.55 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

High mobility group nucleosome-binding domain-containing protein 4 is a transcription factor that in humans is encoded by the HMGN4 gene.

Function

The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Transcript variants utilizing alternative polyadenylation signals exist for this gene.

See also

• High-mobility group

References

1. ^ GRCh38: Ensembl release 89: ENSG00000182952 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ "Entrez Gene: high mobility group nucleosomal binding domain 4".
4. Birger Y, Ito Y, West KL, Landsman D, Bustin M (May 2001). "HMGN4, a newly discovered nucleosome-binding protein encoded by an intronless gene". DNA Cell Biol. 20 (5): 257–64. doi:10.1089/104454901750232454. PMID 11410162.

Further reading

• Ruddy DA, Kronmal GS, Lee VK, et al. (1997). "A 1.1-Mb transcript map of the hereditary hemochromatosis locus". Genome Res. 7 (5): 441–56. doi:10.1101/gr.7.5.441. PMID 9149941.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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