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MEOX2
Identifiers
Aliases	MEOX2, GAX, MOX2, mesenchyme homeobox 2
External IDs	OMIM: 600535; MGI: 103219; HomoloGene: 4330; GeneCards: MEOX2; OMA:MEOX2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p21.2 Start 15,611,212 bp End 15,686,683 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12 A3|12 16.84 cM Start 37,158,539 bp End 37,229,533 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon parietal pleura spinal ganglia tibial nerve synovial joint subcutaneous adipose tissue tendon of biceps brachii saphenous vein sural nerve trigeminal ganglion Top expressed in left lung lobe sciatic nerve lumbar spinal ganglion dermis hand foot ankle human fetus carotid body limb bud More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nuclear speck nucleus Biological process neuron death roof of mouth development regulation of transcription, DNA-templated somite specification blood circulation transcription, DNA-templated limb development multicellular organism development angiogenesis skeletal muscle tissue development positive regulation of transcription by RNA polymerase II negative regulation of cell migration involved in sprouting angiogenesis transcription by RNA polymerase II somite development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4223 17286 Ensembl ENSG00000106511 ENSMUSG00000036144 UniProt P50222 P32443 RefSeq (mRNA) NM_005924 NM_008584 RefSeq (protein) NP_005915 NP_032610 Location (UCSC) Chr 7: 15.61 – 15.69 Mb Chr 12: 37.16 – 37.23 Mb PubMed search
Wikidata
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Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.

Function

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. MEOX2 has been implicated in the initiation of tumors in glioma. Additionally, MEOX2 influences several critical processes in lung cancer, including cellular proliferation, invasion, metastasis, angiogenesis, and the development of drug resistance.

Interactions

MEOX2 has been shown to interact with PAX1 and PAX3.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000106511 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000036144 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. LePage DF, Altomare DA, Testa JR, Walsh K (December 1994). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics. 24 (3): 535–540. doi:10.1006/geno.1994.1663. PMID 7713505.
6. ^ "Entrez Gene: MEOX2 mesenchyme homeobox 2".
7. Wang J, Chen Y, Wang Q, Xu H, Wu C, Jiang Q, et al. (April 2022). "MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma". Cell Death & Disease. 13 (4): 360. doi:10.1038/s41419-022-04845-2. PMC 9016080. PMID 35436995.
8. Armas-López L, Piña-Sánchez P, Arrieta O, de Alba EG, Ortiz-Quintero B, Santillán-Doherty P, et al. (September 2017). "Epigenomic study identifies a novel mesenchyme homeobox2-GLI1 transcription axis involved in cancer drug resistance, overall survival and therapy prognosis in lung cancer patients". Oncotarget. 8 (40): 67056–67081. doi:10.18632/oncotarget.17715. PMC 5620156. PMID 28978016.
9. Peralta-Arrieta I, Trejo-Villegas OA, Armas-López L, Ceja-Rangel HA, Ordóñez-Luna MD, Pineda-Villegas P, et al. (January 2022). "Failure to EGFR-TKI-based therapy and tumoural progression are promoted by MEOX2/GLI1-mediated epigenetic regulation of EGFR in the human lung cancer". European Journal of Cancer. 160: 189–205. doi:10.1016/j.ejca.2021.10.032. PMID 34844838.
10. ^ Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (June 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Letters. 499 (3): 274–278. Bibcode:2001FEBSL.499..274S. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.

Further reading

• Grigoriou M, Kastrinaki MC, Modi WS, Theodorakis K, Mankoo B, Pachnis V, et al. (April 1995). "Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3". Genomics. 26 (3): 550–555. doi:10.1016/0888-7543(95)80174-K. PMID 7607679.
• Reardon W, McManus SP, Summers D, Winter RM (October 1993). "Cytogenetic evidence that the Saethre-Chotzen gene maps to 7p21.2". American Journal of Medical Genetics. 47 (5): 633–636. doi:10.1002/ajmg.1320470510. PMID 8266988.
• Quinn LM, Latham SE, Kalionis B (2000). "The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta". Placenta. 21 Suppl A: S50 – S54. doi:10.1053/plac.1999.0514. PMID 10831122.
• Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (June 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Letters. 499 (3): 274–278. Bibcode:2001FEBSL.499..274S. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.
• Gorski DH, Leal AJ (May 2003). "Inhibition of endothelial cell activation by the homeobox gene Gax". The Journal of Surgical Research. 111 (1): 91–99. doi:10.1016/S0022-4804(03)00042-8. PMID 12842453.
• Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, et al. (September 2005). "Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease". Nature Medicine. 11 (9): 959–965. doi:10.1038/nm1287. PMID 16116430. S2CID 12998034.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Lin J, Friesen MT, Bocangel P, Cheung D, Rawszer K, Wigle JT (July 2005). "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10". Molecular and Cellular Biochemistry. 275 (1–2): 75–84. doi:10.1007/s11010-005-0823-3. PMID 16335786. S2CID 30515981.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Chen Y, Leal AD, Patel S, Gorski DH (January 2007). "The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences". The Journal of Biological Chemistry. 282 (1): 507–517. doi:10.1074/jbc.M606604200. PMC 1865102. PMID 17074759.

External links

• MEOX2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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