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OLIG1
Identifiers
Aliases	OLIG1, BHLHB6, BHLHE21, oligodendrocyte transcription factor 1
External IDs	OMIM: 606385; MGI: 1355334; HomoloGene: 9667; GeneCards: OLIG1; OMA:OLIG1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) Band 21q22.11 Start 33,070,141 bp End 33,072,413 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C3.3 Start 91,066,660 bp End 91,068,821 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve C1 segment external globus pallidus subthalamic nucleus ventral tegmental area substantia nigra Medulla Oblongata Amygdala superior vestibular nucleus putamen Top expressed in optic nerve deep cerebellar nuclei substantia nigra nucleus of stria terminalis spinal cord lumbar subsegment of spinal cord globus pallidus central gray substance of midbrain anterior horn of spinal cord ventral tegmental area More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process multicellular organism development neuron fate commitment oligodendrocyte differentiation regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116448 50914 Ensembl ENSG00000184221 ENSMUSG00000046160 UniProt Q8TAK6 Q9JKN5 RefSeq (mRNA) NM_138983 NM_016968 RefSeq (protein) NP_620450 NP_058664 Location (UCSC) Chr 21: 33.07 – 33.07 Mb Chr 16: 91.07 – 91.07 Mb PubMed search
Wikidata
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Oligodendrocyte transcription factor 1 is a protein that in humans is encoded by the OLIG1 gene.

See also

• Oligodendrocyte
• Transcription factor
• OLIG2

References

1. ^ GRCh38: Ensembl release 89: ENSG00000184221 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000046160 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM (Sep 2001). "Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors". Proceedings of the National Academy of Sciences of the United States of America. 98 (19): 10851–6. Bibcode:2001PNAS...9810851L. doi:10.1073/pnas.181340798. PMC 58563. PMID 11526205.
6. "Entrez Gene: OLIG1 oligodendrocyte transcription factor 1".

Further reading

• Zhou Q, Wang S, Anderson DJ (Feb 2000). "Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors". Neuron. 25 (2): 331–43. doi:10.1016/S0896-6273(00)80898-3. PMID 10719889. S2CID 16560063.
• Takebayashi H, Yoshida S, Sugimori M, Kosako H, Kominami R, Nakafuku M, Nabeshima Y (Dec 2000). "Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3". Mechanisms of Development. 99 (1–2): 143–8. doi:10.1016/S0925-4773(00)00466-4. PMID 11091082. S2CID 1472243.
• McLellan AS, Langlands K, Kealey T (Dec 2002). "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening". Mechanisms of Development. 119 (Suppl 1): S285-91. doi:10.1016/S0925-4773(03)00130-8. PMID 14516699. S2CID 5903576.
• Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD (Dec 2004). "bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS". Science. 306 (5704): 2111–5. Bibcode:2004Sci...306.2111A. doi:10.1126/science.1103709. PMID 15604411. S2CID 31228720.
• Jakovcevski I, Zecevic N (Nov 2005). "Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS". The Journal of Neuroscience. 25 (44): 10064–73. doi:10.1523/JNEUROSCI.2324-05.2005. PMC 6725798. PMID 16267213.
• Goris A, Yeo TW, Maranian M, Walton A, Ban M, Gray J, Compston A, Sawcer S (Nov 2006). "Novel Olig 1-coding variants and susceptibility to multiple sclerosis". Journal of Neurology, Neurosurgery, and Psychiatry. 77 (11): 1296–7. doi:10.1136/jnnp.2006.090639. PMC 2077377. PMID 16820418.
• Ruf N, Martelli M, Weschke B, Uhlenberg B (Apr 2007). "Oligodendroglial transcription factor (OLIG1 and OLIG2) mutations are not associated with Pelizaeus-Merzbacher-like leukodystrophy". American Journal of Medical Genetics Part B. 144B (3): 365–6. doi:10.1002/ajmg.b.30434. PMID 17171653. S2CID 25663863.
• Brena RM, Morrison C, Liyanarachchi S, Jarjoura D, Davuluri RV, Otterson GA, Reisman D, Glaros S, Rush LJ, Plass C (Mar 2007). "Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer". PLOS Medicine. 4 (3): e108. doi:10.1371/journal.pmed.0040108. PMC 1831740. PMID 17388669.

External links

• OLIG1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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• Genes on human chromosome 21
• Transcription factors
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