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ERV3-1
Identifiers
Aliases	ERV3-1, ERV-R, ERV3, ERVR, HERV-R, HERVR, envR, endogenous retrovirus group 3 member 1, endogenous retrovirus group 3 member 1, envelope
External IDs	OMIM: 131170; HomoloGene: 128310; GeneCards: ERV3-1; OMA:ERV3-1 - orthologs
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left adrenal gland monocyte gallbladder ganglionic eminence islet of Langerhans right lung minor salivary glands Achilles tendon appendix right uterine tube n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular function Cellular component viral envelope virion extracellular exosome Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2086 n/a Ensembl n/a n/a UniProt Q14264 n/a RefSeq (mRNA) NM_001007253 NM_001396062 n/a RefSeq (protein) NP_001007254 n/a Location (UCSC) n/a n/a PubMed search n/a
Wikidata
View/Edit Human

HERV-R_7q21.2 provirus ancestral envelope (Env) polyprotein is a protein that in humans is encoded by the ERV3 gene.

Function

The human genome includes many retroelements including the human endogenous retroviruses (HERVs), which compose about 7-8% of the human genome. ERV3, one of the most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates with the exception of gorillas. Taken together, the observation of genome conservation, the detection of transcript expression, and the presence of conserved ORFs is circumstantial evidence for a functional role. Similar endogenous retroviral Env genes like syncytin-1 have important roles in placental formation and embryonic development by enabling cell-cell fusion. Despite its origin as an Env gene, ERV3 has a premature stop codon that precludes any cell-cell fusion functionality. However, it does have an immunosuppressive function that helps the fetus evade a damaging maternal immune response, which may explain its high expression in the placenta.

There is speculation that ERV3 originally did have cell-cell fusion functionality in the placenta, but that it was eventually supplanted by other Env genes like syncytin, leading to a loss of this function.

Another functional role is suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma.

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. Kato N, Shimotohno K, VanLeeuwen D, Cohen M (August 1990). "Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel". Molecular and Cellular Biology. 10 (8): 4401–5. doi:10.1128/mcb.10.8.4401. PMC 361000. PMID 2115127.
3. O'Connell C, O'Brien S, Nash WG, Cohen M (October 1984). "ERV3, a full-length human endogenous provirus: chromosomal localization and evolutionary relationships". Virology. 138 (2): 225–35. doi:10.1016/0042-6822(84)90347-7. PMID 6495650.
4. ^ "Entrez Gene: ERV3 endogenous retroviral sequence 3 (includes zinc finger protein H-plk/HPF9)".
5. Jern P, Coffin JM (December 2008). "Effects of retroviruses on host genome function". Annual Review of Genetics. 42 (1): 709–32. doi:10.1146/annurev.genet.42.110807.091501. PMID 18694346. S2CID 9254616.
6. Vargas A, Moreau J, Landry S, LeBellego F, Toufaily C, Rassart E, et al. (September 2009). "Syncytin-2 plays an important role in the fusion of human trophoblast cells". Journal of Molecular Biology. 392 (2): 301–18. doi:10.1016/j.jmb.2009.07.025. PMID 19616006.
7. Mallet F, Bouton O, Prudhomme S, Cheynet V, Oriol G, Bonnaud B, et al. (February 2004). "The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology". Proceedings of the National Academy of Sciences of the United States of America. 101 (6): 1731–6. Bibcode:2004PNAS..101.1731M. doi:10.1073/pnas.0305763101. PMC 341840. PMID 14757826.
8. de Parseval N, Heidmann T (April 1998). "Physiological knockout of the envelope gene of the single-copy ERV-3 human endogenous retrovirus in a fraction of the Caucasian population". Journal of Virology. 72 (4): 3442–5. doi:10.1128/JVI.72.4.3442-3445.1998. PMC 109847. PMID 9525678.
9. Mangeney M, Renard M, Schlecht-Louf G, Bouallaga I, Heidmann O, Letzelter C, et al. (December 2007). "Placental syncytins: Genetic disjunction between the fusogenic and immunosuppressive activity of retroviral envelope proteins". Proceedings of the National Academy of Sciences of the United States of America. 104 (51): 20534–9. Bibcode:2007PNAS..10420534M. doi:10.1073/pnas.0707873105. PMC 2154466. PMID 18077339.
10. Chuong EB (October 2013). "Retroviruses facilitate the rapid evolution of the mammalian placenta". BioEssays. 35 (10): 853–61. doi:10.1002/bies.201300059. PMC 4332834. PMID 23873343.

Further reading

• Sasaki T (November 1991). "". the Hokkaido Journal of Medical Science. 66 (6): 794–803. PMID 1783368.
• Kato N, Pfeifer-Ohlsson S, Kato M, Larsson E, Rydnert J, Ohlsson R, Cohen M (July 1987). "Tissue-specific expression of human provirus ERV3 mRNA in human placenta: two of the three ERV3 mRNAs contain human cellular sequences". Journal of Virology. 61 (7): 2182–91. doi:10.1128/JVI.61.7.2182-2191.1987. PMC 254242. PMID 2884330.
• Kato N, Larsson E, Cohen M (March 1988). "Absence of expression of a human endogenous retrovirus is correlated with choriocarcinoma". International Journal of Cancer. 41 (3): 380–5. doi:10.1002/ijc.2910410310. PMID 3346101. S2CID 46353425.
• Cohen M, Kato N, Larsson E (February 1988). "ERV3 human endogenous provirus mRNAs are expressed in normal and malignant tissues and cells, but not in choriocarcinoma tumor cells". Journal of Cellular Biochemistry. 36 (2): 121–8. doi:10.1002/jcb.240360203. PMID 3356751. S2CID 24591624.
• Cohen M, Powers M, O'Connell C, Kato N (December 1985). "The nucleotide sequence of the env gene from the human provirus ERV3 and isolation and characterization of an ERV3-specific cDNA". Virology. 147 (2): 449–58. doi:10.1016/0042-6822(85)90147-3. PMID 3840930.
• O'Connell CD, Cohen M (December 1984). "The long terminal repeat sequences of a novel human endogenous retrovirus". Science. 226 (4679): 1204–6. Bibcode:1984Sci...226.1204O. doi:10.1126/science.6505687. PMID 6505687.
• Venables PJ, Brookes SM, Griffiths D, Weiss RA, Boyd MT (August 1995). "Abundance of an endogenous retroviral envelope protein in placental trophoblasts suggests a biological function". Virology. 211 (2): 589–92. doi:10.1006/viro.1995.1442. PMID 7645262.
• Larsson E, Andersson AC, Nilsson BO (1995). "Expression of an endogenous retrovirus (ERV3 HERV-R) in human reproductive and embryonic tissues--evidence for a function for envelope gene products". Upsala Journal of Medical Sciences. 99 (2): 113–20. doi:10.3109/03009739409179354. PMID 7716822.
• Andersson AC, Merza M, Venables P, Pontén F, Sundström J, Cohen M, Larsson E (January 1996). "Elevated levels of the endogenous retrovirus ERV3 in human sebaceous glands". The Journal of Investigative Dermatology. 106 (1): 125–8. doi:10.1111/1523-1747.ep12329612. PMID 8592062.
• Larsson E, Venables P, Andersson AC, Fan W, Rigby S, Botling J, Oberg F, Cohen M, Nilsson K (April 1997). "Tissue and differentiation specific expression on the endogenous retrovirus ERV3 (HERV-R) in normal human tissues and during induced monocytic differentiation in the U-937 cell line". Leukemia. 11 (Suppl 3): 142–4. PMID 9209323.
• Sibata M, Ikeda H, Katumata K, Takeuchi K, Wakisaka A, Yoshoki T (April 1997). "Human endogenous retroviruses: expression in various organs in vivo and its regulation in vitro". Leukemia. 11 (Suppl 3): 145–6. PMID 9209324.
• Andersson AC, Svensson AC, Rolny C, Andersson G, Larsson E (February 1998). "Expression of human endogenous retrovirus ERV3 (HERV-R) mRNA in normal and neoplastic tissues". International Journal of Oncology. 12 (2): 309–13. doi:10.3892/ijo.12.2.309. PMID 9458354.
• de Parseval N, Heidmann T (April 1998). "Physiological knockout of the envelope gene of the single-copy ERV-3 human endogenous retrovirus in a fraction of the Caucasian population". Journal of Virology. 72 (4): 3442–5. doi:10.1128/JVI.72.4.3442-3445.1998. PMC 109847. PMID 9525678.
• Rasmussen HB, Clausen J (November 1998). "Large number of polymorphic nucleotides and a termination codon in the env gene of the endogenous human retrovirus ERV3". Disease Markers. 14 (3): 127–33. doi:10.1155/1998/958379. PMC 3850859. PMID 10427470.
• Lin L, Xu B, Rote NS (January 2000). "The cellular mechanism by which the human endogenous retrovirus ERV-3 env gene affects proliferation and differentiation in a human placental trophoblast model, BeWo". Placenta. 21 (1): 73–8. doi:10.1053/plac.1999.0443. PMID 10692254.
• Kim H, Crow TJ, Hyun BH (2000). "Assignment of the endogenous retrovirus HERV-R (ERV3) to human chromosome 7q11.2 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 89 (1–2): 10. doi:10.1159/000015579. PMID 10894926. S2CID 85042388.
• Andersson AC, Venables PJ, Tönjes RR, Scherer J, Eriksson L, Larsson E (June 2002). "Developmental expression of HERV-R (ERV3) and HERV-K in human tissue". Virology. 297 (2): 220–5. doi:10.1006/viro.2002.1428. PMID 12083821.

External links

• ERV3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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