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YBX3
Identifiers
Aliases	YBX3, CSDA, CSDA1, DBPA, ZONAB, Y-box binding protein 3
External IDs	OMIM: 603437; MGI: 2137670; HomoloGene: 2708; GeneCards: YBX3; OMA:YBX3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.2 Start 10,699,089 bp End 10,723,323 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 F3 Start 131,341,818 bp End 131,365,439 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle Skeletal muscle tissue of rectus abdominis muscle of thigh body of tongue Skeletal muscle tissue of biceps brachii vastus lateralis muscle tibialis anterior muscle deltoid muscle triceps brachii muscle thoracic diaphragm Top expressed in seminiferous tubule blood medial head of gastrocnemius muscle external carotid artery internal carotid artery muscle of thigh quadriceps femoris muscle intercostal muscle digastric muscle hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity DNA-binding transcription factor activity mRNA 3'-UTR binding single-stranded DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific nucleic acid binding double-stranded DNA binding RNA binding DNA-binding transcription factor activity, RNA polymerase II-specific protein binding polysome binding Cellular component polysome bicellular tight junction perinuclear region of cytoplasm nucleus cytoplasm cytosol Biological process male gonad development regulation of transcription, DNA-templated negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress negative regulation of necroptotic process positive regulation of cytoplasmic translation cellular response to tumor necrosis factor positive regulation of organ growth negative regulation of apoptotic process in utero embryonic development negative regulation of transcription by RNA polymerase II transcription, DNA-templated cellular hyperosmotic response negative regulation of skeletal muscle tissue development spermatogenesis response to cold fertilization 3'-UTR-mediated mRNA stabilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8531 56449 Ensembl ENSG00000060138 ENSMUSG00000030189 UniProt P16989 Q9JKB3 RefSeq (mRNA) NM_001145426 NM_003651 NM_011733 NM_139117 RefSeq (protein) NP_001138898 NP_003642 NP_035863 NP_620817 Location (UCSC) Chr 12: 10.7 – 10.72 Mb Chr 6: 131.34 – 131.37 Mb PubMed search
Wikidata
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DNA-binding protein A is a protein that in humans is encoded by the CSDA gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000060138 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030189 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sakura H, Maekawa T, Imamoto F, Yasuda K, Ishii S (Jun 1989). "Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology". Gene. 73 (2): 499–507. doi:10.1016/0378-1119(88)90514-8. PMID 2977358.
6. Coles LS, Diamond P, Occhiodoro F, Vadas MA, Shannon MF (Sep 1996). "Cold shock domain proteins repress transcription from the GM-CSF promoter". Nucleic Acids Res. 24 (12): 2311–7. doi:10.1093/nar/24.12.2311. PMC 145951. PMID 8710501.
7. "Entrez Gene: CSDA cold shock domain protein A".

Further reading

• Lloberas J, Soler C, Celada A (1998). "Repression mechanisms of the I-A beta gene of the major histocompatibility complex". Immunobiology. 198 (1–3): 249–63. doi:10.1016/s0171-2985(97)80045-9. PMID 9442396.
• Kudo S, Mattei MG, Fukuda M (1995). "Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain". Eur. J. Biochem. 231 (1): 72–82. doi:10.1111/j.1432-1033.1995.tb20672.x (inactive 23 December 2024). PMID 7628487.{{cite journal}}: CS1 maint: DOI inactive as of December 2024 (link)
• Funke B, Zuleger B, Benavente R, et al. (1996). "The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins". Nucleic Acids Res. 24 (19): 3821–8. doi:10.1093/nar/24.19.3821. PMC 146158. PMID 8871564.
• Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.
• Hayashi J, Kajino K, Umeda T, et al. (2003). "Somatic mutation and SNP in the promoter of dbpA and human hepatocarcinogenesis". Int. J. Oncol. 21 (4): 847–50. doi:10.3892/ijo.21.4.847. PMID 12239625.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Coles LS, Bartley MA, Bert A, et al. (2004). "A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA. Potential role in mRNA stabilization". Eur. J. Biochem. 271 (3): 648–60. doi:10.1111/j.1432-1033.2003.03968.x. PMID 14728692.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Frankel P, Aronheim A, Kavanagh E, et al. (2005). "RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity". EMBO J. 24 (1): 54–62. doi:10.1038/sj.emboj.7600497. PMC 544910. PMID 15592429.
• Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Sourisseau T, Georgiadis A, Tsapara A, et al. (2006). "Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA". Mol. Cell. Biol. 26 (6): 2387–98. doi:10.1128/MCB.26.6.2387-2398.2006. PMC 1430269. PMID 16508013.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• CSDA+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human YBX3 genome location and YBX3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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