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Members of the nuclear receptor family of intracellular transcription factors
The RAR-related orphan receptors (RORs) are members of the nuclear receptor family of intracellulartranscription factors. There are three forms of ROR, ROR-α, -β, and -γ and each is encoded by a separate gene, RORA, RORB, and RORC respectively. The RORs are somewhat unusual in that they appear to bind as monomers to hormone response elements as opposed to the majority of other nuclear receptors which bind as dimers. They bind to DNA elements called ROR response elements (RORE).
Ligands
While the identity of natural ligands for the RORs remains controversial, similar to the liver X receptors (LXRs), it appears that the RORs are activated by oxysterols. Furthermore, the RORs appear to be constitutively active (absence of ligand) and that activity may be due to continuously bound natural ligands. Side chain oxygenated sterols (e.g., 20α-hydroxycholesterol, 22R-hydroxycholesterol, and 25-hydroxycholesterol) are high affinity RORγ agonists while sterols oxygenated at the 7-position, (e.g., (7-hydroxycholesterol and 7-ketocholesterol) function as inverse agonists for both RORa and RORγ. A number of other natural substances have also been reported to bind to the RORs. These include all-trans retinoic acid binds with high affinity to ROR-β and -γ but not ROR-α. Finally the RORs may function as lipid sensors and hence may play a role in the regulation of lipid metabolism.
Melatonin has been claimed to be an endogenous ligand for ROR-α while CGP 52608 has been identified as a ROR-α selective synthetic ligand.
Tissue distribution
RORα, RORβ, and RORγ are primarily expressed the following tissues:
ROR-α – widely expressed in liver, skeletal muscle, skin, lung, adipose tissue, kidney, thymus, and brain.
ROR-β – expression restricted to the brain and retina.
ROR-γ – highly expressed in thymus (the thymus-specific isoform is referred to as RORγt), muscle, testis, pancreas, prostate, heart, and liver.
Function
The three forms of RORs fulfill a number of critical roles including:
ROR-β – Circadian rhythm, bone metabolism, and retinal neurogenesis.
ROR-γ – Lymph node development and immune response, survival of T helper 17 cells.
As drug targets
A number of synthetic RORγt inverse agonists are in various stages of drug development for the treatment of inflammatory diseases. RORγt agonists have also been proposed for use as immunooncology agents to activate the immune system to treat cancer.
Jetten AM (December 2004). "Recent advances in the mechanisms of action and physiological functions of the retinoid-related orphan receptors (RORs)". Current Drug Targets. Inflammation and Allergy. 3 (4): 395–412. doi:10.2174/1568010042634497. PMID15584888.
Chang MR, Rosen H, Griffin PR (2014). "RORs in Autoimmune Disease". Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases. Current Topics in Microbiology and Immunology. Vol. 378. pp. 171–82. doi:10.1007/978-3-319-05879-5_8. ISBN978-3-319-05878-8. PMID24728598.
