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TLX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3A03
Identifiers
Aliases	TLX2, HOX11L1, NCX, T-cell leukemia homeobox 2, T cell leukemia homeobox 2
External IDs	OMIM: 604240; MGI: 1350935; HomoloGene: 7575; GeneCards: TLX2; OMA:TLX2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p13.1 Start 74,513,463 bp End 74,517,148 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 C3|6 35.94 cM Start 83,045,305 bp End 83,047,274 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad transverse colon mucosa of transverse colon muscle layer of sigmoid colon right testis left testis primary visual cortex rectum duodenum appendix Top expressed in lumbar spinal ganglion adrenal medulla autonomic nervous system glossopharyngeal ganglion parasympathetic nervous system female urethra male urethra autonomic ganglion sympathetic nervous system cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component cytoplasm nucleus cellular component Biological process multicellular organism development enteric nervous system development mesoderm formation regulation of transcription, DNA-templated negative regulation of dendrite morphogenesis transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3196 21909 Ensembl ENSG00000115297 ENSMUSG00000068327 UniProt O43763 Q61663 RefSeq (mRNA) NM_016170 NM_001534 NM_009392 RefSeq (protein) NP_057254 NP_033418 Location (UCSC) Chr 2: 74.51 – 74.52 Mb Chr 6: 83.05 – 83.05 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

T-cell leukemia homeobox protein 2 is a protein that in humans is encoded by the TLX2 gene.

Interactions

TLX2 has been shown to interact with YWHAH.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000115297 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000068327 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Puliti A, Cinti R, Betsos N, Romeo G, Ceccherini I (Jun 1999). "HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1→p12 and mouse chromosome 6C3-D1". Cytogenetics and Cell Genetics. 84 (1–2): 115–7. doi:10.1159/000015234. PMID 10343123. S2CID 21498122.
6. "Entrez Gene: TLX2 T-cell leukemia homeobox 2".
7. Tang SJ, Suen TC, McInnes RR, Buchwald M (September 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins". The Journal of Biological Chemistry. 273 (39): 25356–63. doi:10.1074/jbc.273.39.25356. PMID 9738002.

Further reading

• Kaifi JT, Wagner M, Schurr PG, Wachowiak R, Reichelt U, Yekebas EF, Mann O, Vashist Y, Kleinhans H, Link BC, Strate T, Kalinin V, Izbicki JR (October 2006). "Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors". Oncology Reports. 16 (4): 915–9. doi:10.3892/or.16.4.915. PMID 16969514.
• Borghini S, Bachetti T, Fava M, Di Duca M, Cargnin F, Fornasari D, Ravazzolo R, Ceccherini I (April 2006). "The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells". The Biochemical Journal. 395 (2): 355–61. doi:10.1042/BJ20051386. PMC 1422762. PMID 16402914.
• Parisi MA, Lipman NS, Clarke CM, Taylor B, Kapur RP (November 2005). "Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction". Journal of Pediatric Surgery. 40 (11): 1760–5. doi:10.1016/j.jpedsurg.2005.07.010. PMID 16291166.
• Iitsuka Y, Shimizu H, Kang MM, Sasagawa K, Sekiya S, Tokuhisa T, Hatano M (August 1999). "An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells". The Journal of Biological Chemistry. 274 (34): 24401–7. doi:10.1074/jbc.274.34.24401. PMID 10446220.
• Tang SJ, Suen TC, McInnes RR, Buchwald M (September 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins". The Journal of Biological Chemistry. 273 (39): 25356–63. doi:10.1074/jbc.273.39.25356. PMID 9738002.

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