Misplaced Pages

SOX12
Identifiers
Aliases	SOX12, SOX22, SRY-box 12, SRY-box transcription factor 12
External IDs	OMIM: 601947; MGI: 98360; HomoloGene: 5057; GeneCards: SOX12; OMA:SOX12 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20p13 Start 325,552 bp End 330,224 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 G3 Start 152,235,531 bp End 152,239,983 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone stromal cell of endometrium apex of heart right hemisphere of cerebellum right uterine tube right adrenal cortex sural nerve right ovary right frontal lobe Top expressed in aortic valve Gonadal ridge genital tubercle somite ventricular zone ascending aorta maxillary prominence mandibular prominence internal carotid artery external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription coactivator activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription cis-regulatory region binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component protein-DNA complex nucleus nucleoplasm cellular component Biological process regulation of transcription by RNA polymerase II protein-DNA complex assembly cell fate commitment regulation of transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II spinal cord development transcription, DNA-templated cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6666 20667 Ensembl ENSG00000177732 ENSMUSG00000051817 UniProt O15370 Q04890 RefSeq (mRNA) NM_006943 NM_011438 RefSeq (protein) NP_008874 NP_035568 Location (UCSC) Chr 20: 0.33 – 0.33 Mb Chr 2: 152.24 – 152.24 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

SOX12 is a protein that in humans is encoded by the SOX12 gene. Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11. Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000177732 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000051817 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jay P, Sahly I, Goze C, Taviaux S, Poulat F, Couly G, Abitbol M, Berta P (Aug 1997). "SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue". Hum Mol Genet. 6 (7): 1069–77. doi:10.1093/hmg/6.7.1069. PMID 9215677.
6. ^ "Entrez Gene: SOX12 SRY (sex determining region Y)-box 12".
7. Hoser M, Potzner MR, Koch JM, Bösl MR, Wegner M, Sock E (August 2008). "Sox12 Deletion in the Mouse Reveals Nonreciprocal Redundancy with the Related Sox4 and Sox11 Transcription Factors". Mol. Cell. Biol. 28 (15): 4675–87. doi:10.1128/MCB.00338-08. PMC 2493363. PMID 18505825.
8. Dy P, Penzo-Méndez A, Wang H, Pedraza CE, Macklin WB, Lefebvre V (May 2008). "The three SoxC proteins—Sox4, Sox11 and Sox12—exhibit overlapping expression patterns and molecular properties". Nucleic Acids Res. 36 (9): 3101–17. doi:10.1093/nar/gkn162. PMC 2396431. PMID 18403418.

Further reading

• Bowles J, Schepers G, Koopman P (2001). "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators". Dev. Biol. 227 (2): 239–55. doi:10.1006/dbio.2000.9883. PMID 11071752.
• Weiss MA (2001). "Floppy SOX: mutual induced fit in hmg (high-mobility group) box-DNA recognition". Mol. Endocrinol. 15 (3): 353–62. doi:10.1210/mend.15.3.0617. PMID 11222737.
• Gozé C, Poulat F, Berta P (1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes". Nucleic Acids Res. 21 (12): 2943. doi:10.1093/nar/21.12.2943. PMC 309692. PMID 8332506.

This article on a gene on human chromosome 20 is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome 20
• Transcription factors
• Human chromosome 20 gene stubs